LOCUS       HUME2F       2517 bp    mRNA            PRI       10-AUG-1992
DEFINITION  Homo sapiens (E2F-1) pRB-binding protein mRNA, complete cds.
ACCESSION   M96577
NID         g181917
KEYWORDS    DNA-binding protein; pRB-binding protein; transcription factor E2F.
SOURCE      Homo sapiens fetal brain cDNA to mRNA.
  ORGANISM  Homo sapiens
            Eukaryotae; mitochondrial eukaryotes; Metazoa; Chordata;
            Vertebrata; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2517)

AUTHORS  Kaelin, W.G., Krek, W., Sellers, W.R., DeCaprio, J.A., Ajchenbaum, F., 
Fuchs, C.S., Chittenden, T., Li, Y., Farnham, P.J., Blanar, M.A., Livingston, D.M., 
and Flemington, E.K.
 TITLE     Expression cloning of a cDNA encoding a Retinoblastoma-Binding 
Protein with E2F-like proterties.

  AUTHORS   Helin,K., Lees,J.A., Vidal,M., Dyson,N.J., Harlow,E. and Fattaey,A.
  TITLE     A cDNA encoding a pRB-binding protein with properties of the
            transcription factor E2F
  JOURNAL   Cell 70, 337-350 (1992)
  MEDLINE   92346720
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Homo sapiens"
                     /cell_line="Nalm 6"
                     /cell_type="pre B-cells"
                     /dev_stage="fetal"
                     /tissue_type="brain"
     CDS             136..1449
                     /note="pRB-binding protein"
                     /codon_start=1
                     /product="E2F-1"
                     /db_xref="PID:g181918"
                     /translation="MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASA
                     PPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLA
                     ESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVL
                     KVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQ
                     QLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAV
                     DSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPP
                     PSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFS
                     GLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF"
BASE COUNT      454 a    784 c    781 g    498 t
ORIGIN
        1 ggaattccgt ggccgggact ttgcaggcag cggcggccgg gggcggagcg ggatcgagcc
       61 ctcgccgagg cctgccgcca tgggcccgcg ccgccgccgc cgcctgtcac ccgggccgcg
      121 cgggccgtga gcgtcatggc cttggccggg gcccctgcgg gcggcccatg cgcgccggcg
      181 ctggaggccc tgctcggggc cggcgcgctg cggctgctcg actcctcgca gatcgtcatc
      241 atctccgccg cgcaggacgc cagcgccccg ccggctccca ccggccccgc ggcgcccgcc
      301 gccggcccct gcgaccctga cctgctgctc ttcgccacac cgcaggcgcc ccggcccaca
      361 cccagtgcgc cgcggcccgc gctcggccgc ccgccggtga agcggaggct ggacctggaa
      421 actgaccatc agtacctggc cgagagcagt gggccagctc ggggcagagg ccgccatcca
      481 ggaaaaggtg tgaaatcccc gggggagaag tcacgctatg agacctcact gaatctgacc
      541 accaagcgct tcctggagct gctgagccac tcggctgacg gtgtcgtcga cctgaactgg
      601 gctgccgagg tgctgaaggt gcagaagcgg cgcatctatg acatcaccaa cgtccttgag
      661 ggcatccagc tcattgccaa gaagtccaag aaccacatcc agtggctggg cagccacacc
      721 acagtgggcg tcggcggacg gcttgagggg ttgacccagg acctccgaca gctgcaggag
      781 agcgagcagc agctggacca cctgatgaat atctgtacta cgcagctgcg cctgctctcc
      841 gaggacactg acagccagcg cctggcctac gtgacgtgtc aggaccttcg tagcattgca
      901 gaccctgcag agcagatggt tatggtgatc aaagcccctc ctgagaccca gctccaagcc
      961 gtggactctt cggagaactt tcagatctcc cttaagagca aacaaggccc gatcgatgtt
     1021 ttcctgtgcc ctgaggagac cgtaggtggg atcagccctg ggaagacccc atcccaggag
     1081 gtcacttctg aggaggagaa cagggccact gactctgcca ccatagtgtc accaccacca
     1141 tcatctcccc cctcatccct caccacagat cccagccagt ctctactcag cctggagcaa
     1201 gaaccgctgt tgtcccggat gggcagcctg cgggctcccg tggacgagga ccgcctgtcc
     1261 ccgctggtgg cggccgactc gctcctggag catgtgcggg aggacttctc cggcctcctc
     1321 cctgaggagt tcatcagcct ttccccaccc cacgaggccc tcgactacca cttcggcctc
     1381 gaggagggcg agggcatcag agacctcttc gactgtgact ttggggacct cacccccctg
     1441 gatttctgac agggcttgga gggaccaggg tttccagagt agctcacctt gtctctgcag
     1501 ccctggagcc ccctgtccct ggccgtcctc ccagcctgtt tggaaacatt taatttatac
     1561 ccctctcctc tgtctccaga agcttctagc tctggggtct ggctaccgct aggaggctga
     1621 gcaagccagg aagggaagga gtctgtgtgg tgtgtatgtg catgcagcct acacccacac
     1681 gtgtgtaccg ggggtgaatg tgtgtgagca tgtgtgtgtg catgtaccgg ggaatgaagg
     1741 tgaacataca cctctgtgtg tgcactgcag acacgcccca gtgtgtccac atgtgtgtgc
     1801 atgagtccat ctctgcgcgt gggggggctc taactgcact ttcggccctt ttgctcgtgg
     1861 ggtcccacaa ggcccagggc agtgcctgct cccagaatct ggtgctctga ccaggccagg
     1921 tggggaggct ttggctggct gggcgtgtag gacggtgaga gcacttctgt cttaaaggtt
     1981 ttttctgatt gaagctttaa tggagcgtta tttatttatc gaggcctctt tggtgagcct
     2041 ggggaatcag caaaagggga ggaggggtgt ggggttgata ccccaactcc ctctaccctt
     2101 gagcaagggc aggggtccct gagctgttct tctgccccat actgaaggaa ctgaggcctg
     2161 ggtgatttat ttattgggaa agtgagggag ggagacagac tgactgacag ccatgggtgg
     2221 tcagatggtg gggtgggccc tctccagggg gccagttcag ggcccagctg ccccccagga
     2281 tggatatgag atgggagagg tgagtggggg accttcactg atgtgggcag gaggggtggt
     2341 gaaggcctcc cccagcccag accctgtggt ccctcctgca gtgtctgaag cgcctgcctc
     2401 cccactgctc tgccccaccc tccaatctgc actttgattt gcttcctaac agctctgttc
     2461 cctcctgctt tggttttaat aaatattttg atgacgttaa aaaaaggaat tcgatat
//