EBV Genomic Sequence (B95-8)
This document contains references, Orfs, and entire genomic sequence
LOCUS EBV 172281 bp DNA circular VRL 29-OCT-1996
DEFINITION Epstein-Barr virus (EBV) genome. The complete sequence [1-10] was
determined from DNA from B95-8 cells cloned by Arrand et al [11].
B95-8 is a productive marmoset lymphoblastoid cell line
immortalized with human EBV from a mononucleosis patient.
ACCESSION V01555 J02070 K01729 K01730 V01554 X00498 X00499 X00784
NID g59074
KEYWORDS DNA polymerase; EBNA; genome; ribonucleotide reductase; tandem
repeat; terminal repeat.
SOURCE Epstein-Barr virus.
ORGANISM Human herpesvirus 4
Viruses; dsDNA viruses, no RNA stage; Herpesviridae;
Gammaherpesvirinae; Lymphocryptovirus.
REFERENCE 1 (bases 1 to 172281)
AUTHORS Baer,R.J., Bankier,A.T., Biggin,M.D., Deininger,P.L., Farrell,P.J.,
Gibson,T.J., Hatfull,G.F., Hudson,G.S., Satchwell,S.C., Seguin,C.,
Tuffnell,P.S. and Barrell,B.G.
TITLE DNA sequence and expression of the B95-8 Epstein-Barr virus genome
JOURNAL Nature 310 (5974), 207-211 (1984)
MEDLINE 84270667
REFERENCE 2 (bases 1 to 172281)
AUTHORS Deininger,P.L., Bankier,A., Farrell,P., Baer,R. and Barrell,B.
TITLE Sequence analysis and in vitro transcription of portions of the
Epstein-Barr virus genome
JOURNAL J. Cell. Biochem. 19 (3), 267-274 (1982)
MEDLINE 83109311
REFERENCE 3 (bases 1 to 172281)
AUTHORS Farrell,P.J., Deininger,P.L., Bankier,A. and Barrell,B.
TITLE Homologous upstream sequences near Epstein-Barr virus promoters
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80 (6), 1565-1569 (1983)
MEDLINE 83169725
REFERENCE 4 (bases 1 to 172281)
AUTHORS Farrell,P.J., Bankier,A.T., Seguin,C., Deininger,P.L. and
Barrell,B.G.
TITLE Latent and lytic cycle promoters of Epstein-Barr virus
JOURNAL EMBO J. 2, 1331-1338 (1983)
REFERENCE 5 (bases 142687 to 159853)
AUTHORS Bankier,A.T., Deininger,P.L., Farrell,P.J. and Barrell,B.G.
TITLE Sequence analysis of the 17,166 base-pair EcoRI fragment C of B95-8
Epstein-Barr virus
JOURNAL Mol. Biol. Med. 1 (1), 21-45 (1983)
MEDLINE 85035713
REFERENCE 6 (bases 112620 to 125316)
AUTHORS Seguin,C., Farrell,P.J. and Barrell,B.G.
TITLE DNA sequence and transcription of the BamHI fragment B region of
B95-8 Epstein-Barr virus
JOURNAL Mol. Biol. Med. 1 (3), 369-392 (1983)
MEDLINE 85060424
REFERENCE 7 (bases 159853 to 172281)
AUTHORS Bankier,A.T., Deininger,P.L., Satchwell,S.C., Baer,R., Farrell,P.J.
and Barrell,B.G.
TITLE DNA sequence analysis of the EcoRI Dhet fragment of B95-8
Epstein-Barr virus containing the terminal repeat sequences
JOURNAL Mol. Biol. Med. 1 (4), 425-445 (1983)
MEDLINE 85060428
REFERENCE 8 (bases 87650 to 92703)
AUTHORS Biggin,M., Farrell,P.J. and Barrell,B.G.
TITLE Transcription and DNA sequence of the BamHI L fragment of B95-8
Epstein-Barr virus
JOURNAL EMBO J. 3 (5), 1083-1090 (1984)
MEDLINE 84236104
REFERENCE 9 (bases 76089 to 79808)
AUTHORS Gibson,T., Stockwell,P., Ginsburg,M. and Barrell,B.
TITLE Homology between two EBV early genes and HSV ribonucleotide
reductase and 38K genes
JOURNAL Nucleic Acids Res. 12 (12), 5087-5099 (1984)
MEDLINE 84247360
REFERENCE 10 (bases 1 to 172281)
AUTHORS Hatfull,G.F., Barrell,B.G., Quinn,J. and McGeoch,D.
JOURNAL Unpublished
REFERENCE 11 (bases 1 to 172281)
AUTHORS Arrand,J.R., Rymo,L., Walsh,J.E., Bjorck,E., Lindahl,T. and
Griffin,B.E.
TITLE Molecular cloning of the complete Epstein-Barr virus genome as a
set of overlapping restriction endonuclease fragments
JOURNAL Nucleic Acids Res. 9 (13), 2999-3014 (1981)
MEDLINE 82014887
REFERENCE 12 (bases 1 to 172281)
AUTHORS Kozak,M.
TITLE Possible role of flanking nucleotides in recognition of the AUG
initiator codon by eukaryotic ribosomes
JOURNAL Nucleic Acids Res. 9 (20), 5233-5262 (1981)
MEDLINE 82059504
REFERENCE 13 (bases 7315 to 9312)
AUTHORS Yates,J., Warren,N., Reisman,D. and Sugden,B.
TITLE A cis-acting element from the Epstein-Barr viral genome that
permits stable replication of recombinant plasmids in latently
infected cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81 (12), 3806-3810 (1984)
MEDLINE 84222045
REFERENCE 14 (bases 45415 to 52824)
AUTHORS Jones,M.D., Foster,L., Sheedy,T. and Griffin,B.E.
TITLE The EB virus genome in Daudi Burkitt's lymphoma cells has a
deletion similar to that observed in a non-transforming strain
(P3HR-1) of the virus
JOURNAL EMBO J. 3 (4), 813-821 (1984)
MEDLINE 84207939
REFERENCE 15 (bases 45644 to 52450)
AUTHORS Jeang,K.T. and Hayward,S.D.
TITLE Organization of the Epstein-Barr virus DNA molecule. III. Location
of the P3HR-1 deletion junction and characterization of the NotI
repeat units that form part of the template for an abundant
12-O-tetradecanoylphorbol-13-acetate-induced mRNA transcript
JOURNAL J. Virol. 48 (1), 135-148 (1983)
MEDLINE 83294686
REFERENCE 16 (bases 1 to 172281)
AUTHORS Farrell,P.J. and Barrell,B.G.
TITLE Direct Submission
JOURNAL Submitted (05-JUN-1984) to the EMBL/GenBank/DDBJ databases
REFERENCE 17 (bases 1 to 172281)
AUTHORS Bodescot,M. and Perricaudet,M.
TITLE Clustered alternative splice sites in Epstein-Barr virus RNAs
JOURNAL Nucleic Acids Res. 15 (14), 5887 (1987)
MEDLINE 87289053
REFERENCE 18 (bases 1 to 172281)
AUTHORS Laux,G., Perricaudet,M. and Farrell,P.J.
TITLE A spliced Epstein-Barr virus gene expressed in immortalized
lymphocytes is created by circularization of the linear viral
genome
JOURNAL EMBO J. 7 (3), 769-774 (1988)
MEDLINE 88283646
REFERENCE 19 (bases 1 to 172281)
AUTHORS Farrell,P.J.
TITLE Direct Submission
JOURNAL Submitted (18-MAR-1988) Farrell P., Ludwig Institute for Cancer
Research, St. Mary's Hospital Medical School, Norfolk Place London
W2 1PG
COMMENT CDS
Listed under this feature are all known protein coding regions as
well as all the major open reading frames in the sequence. In
general the term major is taken as the longest frame in a
particular region taking into account the adjacent longest frames
and likely transcription signals. Note that on this basis some long
overlapping frames have been excluded and on the other hand some
small frames have been included which might represent exons or
genes because they occur in a logical combination with other
features or because of some other experimental data. The reading
frames are named according to the Bam H1 fragment in which they
start. eg BALF3 is the third leftward frame starting in Bam H1
fragment A. BORF1 is the first rightward frame in Bam H1 fragment
O. If there is an obvious TATA sequence followed by an in frame Met
codon that satisfies the rules of Kozak [12] in that there is a
purine at -3 and/or a G at +4 then the reading frame is numbered
from the A of the ATG to the base preceding the termination codon.
If there is no obvious initiation codon or there is a substantial
reading frame in phase before the ATG then the reading frame is
numbered from the first base of the first codon.
SITEs of POLYA signals
This feature lists all occurences of the sequence AATAAA which is
found normally approximately 20 bases upstream of the mRNA
processing/polyA addition site. The rarely used homolog ATTAAA is
only listed when it is found in a position close to the end of a
major reading frame.
SITEs of DONOR and ACCEPT sequences
This is not a comprehensive listing of all such sequences and only
the positions of a few have been noted because they occur in
potentially interesting positions. The number quoted in the table
is the position of the terminal base in the intron in each case.
Restriction enzyme SITEs.
Only the positions of the sites Bam HI (BAM) are listed.
RPT
This feature is used to define repetitive sequences.
SITE DEL
This feature defines deletions in B95-8 with respect to other
strains such as RAJI and also to deletions in other strains such as
P3HR1 and DAUDI with respect to B95-8.
SITE HPN
Denotes sequences with twofold symmetry ie could form hairpin
loops. This is not a comprehensive list - only a few occurences
noted.
ORGRPL
Denotes the region that encompasses an origin of replication (ori
P).[13].
NUMBERING
The DNA sequence of B95-8 EBV has been revised [19]. The original
(Baer et al, 1984) base 359 has been deleted so the new sequence
around that position reads TCAGTCTTT. To avoid renumbering the
entire sequence, position 1 has benn moved 1 base to the left of
the EcoRI site separating EcoRI Dhet from EcoRI I
(ie the first A of AGAATTC).
FEATURES Location/Qualifiers
source 1..172281
/organism="Human herpesvirus 4"
/strain="B95-8"
mRNA 58..272
/note="exon 2 terminal protein RNA"
mRNA 360..458
/note="exon 3 terminal protein RNA"
misc_feature complement(535)
/note="polyA signal: AATAAA"
mRNA 540..788
/note="exon 4 terminal protein RNA"
mRNA 871..951
/note="exon 5 terminal protein RNA"
mRNA 1026..1196
/note="exon 6 terminal protein RNA"
promoter complement(1192)
/note="TATA: TATAAAT"
mRNA 1280..1495
/note="exon 7 terminal protein RNA"
promoter complement(1383)
/note="TATA: CATAAAA"
mRNA 1574..1682
/note="exon 8 terminal protein RNA"
promoter 1676
/note="TATA: TATAAAG"
promoter 1691
/note="TATA: TATTAAA BN-R1 late promoter before BNRF1,
gives 4.1kb late RNA. Probably encodes non glycosylated
140kd protein in membrane antigen. Also two latent RNAs
spliced underneath this RNA, lengths 1.8 and 2.0kb (Hudson
et al, 1985). The longer one encodes terminal protein."
CDS 1736..5692
/note="BNRF1 reading frame, 5 NXT/S"
/codon_start=1
/db_xref="PID:g59075"
/db_xref="SWISS-PROT:P03179"
/translation="MEERGRETQMPVARYGGPFIMVRLFGQDGEANIQEERLYELLSD
PRSALGLDPGPLIAENLLLVALRGTNNDPRPQRQERARELALVGILLGNGEQGEHLGT
ESALEASGNNYVYAYGPDWMARPSTWSAEIQQFLRLLGATYVLRVEMGRQFGFEVHRS
RPSFRQFQAINHLVLFDNALRKYDSGQVAAGFQRALLVAGPETADTRPDLRKLNEWVF
GGRAAGGRQLADELKIVSALRDTYSGHLVLQPTETLDTWKVLSRDTRTAHSLEHGFIH
AAGTIQANCPQLFMRRQHPGLFPFVNAIASSLGWYYQTATGPGADARAAARRQQAFQT
RAAAECHAKSGVPVVAGFYRTINATLKGGEGLQPTMFNGELGAIKHQALDTVRYDYGH
YLIMLGPFQPWSGLTAPPCPYAESSWAQAAVQTALELFSALYPAPCISGYARPPGPSA
VIEHLGSLVPKGGLLLFLSHLPDDVKDGLGEMGPARATGPGMQQFVSSYFLNPACSNV
FITVRQRGEKINGRTVLQALGRACDMAGCQHYVLGSTVPLGGLNFVNDLASPVSTAEM
MDDFSPFFTVEFPPIQEEGASSPVPLDVDESMDISPSYELPWLSLESCLTSILSHPTV
GSKEHLVRHTDRVSGGRVAQQPGVGPLDLPLADYAFVAHSQVWTRPGGAPPLPYRTWD
RMTEKLLVSAKPGGENVKVSGTVITLGEQGYKVSLDLREGTRLAMAEALLNAACAPIL
DPEDVLLTLHLHLDPRRADNSAVMEAMTAASDYARGLGVKLTFGSASCPETGSSASNF
MTVVASVSAPGEFSGPLITPVLQKTGSLLIAVRCGDGKIQGGSLFEQLFSDVATTPRA
PEALSLKNLFRAVQQLVKSGIVLSGHDISDGGLVTCLVEMALAGQRGVTITMPVASDY
LPEMFAEHPGLVFEVEERSVGEVLQTLRSMNMYPAVLGRVGEQGPDQMFEVQHGPETV
LRQSLRLLLGTWSSFASEQYECLRPDRINRSMHVSDYGYNEALAVSPLTGKNLSPRRL
VTEPDPRCQVAVLCAPGTRGHESLLAAFTNAGCLCRRVFFREVRDNTFLDKYVGLAIG
GVHGARDSALAGRATVALINRFPALRDAILKFLNRPDTFSVALGELGVQVLAGLGAVG
STDNPPAPGVEVNVQRSPLILAPNASGMFESRWLNISIPATTSSVMLRGLRGCVLPCW
VQGSCLGLQFTNLGMPYVLQNAHQIACHFHSNGTDAWRFAMNYPRNPTEQGNIAGLCS
RDGRHLALLCDPSLCTDFWQWEHIPPAFGHPTGCSPWTLMFQAAHLWSLRHGRPSE"
misc_feature complement(1795)
/note="polyA signal: AATAAA"
misc_feature 3955
/note="BAM: Bam H1 Nhet/h"
misc_feature 3994
/note="BAM: Bam H1 h/C"
mRNA 5408..5856
/note="exon 9 terminal protein RNA"
misc_feature 5841
/note="polyA signal: AATAAA, end of 4.1kb late RNA and TP
latent RNA."
misc_feature 5863
/note="alternative end to TP cDNAs"
promoter 6097
/note="TATA: TATAAGA"
misc_feature 6629..6795
/note="Pol III RNA EBER 1"
promoter complement(6823)
/note="TATA: CATAAAT"
misc_feature 6956..7128
/note="Pol III RNA EBER 2"
rep_origin 7315..9312
/note="origin of replication, ori P (Yates et al, 1984,
1985)"
repeat_region 7421..8042
/note="21x30bp repeats, binding sites for EBNA-1 (site I,
Rawlins et al, 1985). Tandem repeat part of oriP (Reisman
et al, 1985). Also functions as a cell type specific
enhancer (Reisman et al, 1985; Lupton and Levine, 1985)"
promoter 7738
/note="TATA: TATAAAT"
promoter 7888
/note="TATA: TATAAAT"
promoter 8573
/note="TATA: CATAAAT"
misc_feature complement(8680)
/note="polyA signal: AATAAA"
misc_feature complement(8755)
/note="polyA signal: AATAAA"
misc_feature 8962
/note="polyA signal: AATAAA"
misc_feature 9021..9133
/note="HPN: dyad symmetry, site II for EBNA-1 binding
(Rawlins et al, 1985). Dyad symmetry part of oriP (Reisman
et al, 1985)"
promoter complement(9398)
/note="TATA: TATAAAT"
promoter 9631
/note="TATA: TATAAAT BC-R1 late promoter before BCRF1"
CDS 9675..10187
/note="BCRF1 reading frame"
/codon_start=1
/db_xref="PID:g59076"
/db_xref="SWISS-PROT:P03180"
/translation="MERRLVVTLQCLVLLYLAPECGGTDQCDNFPQMLRDLRDAFSRV
KTFFQTKDEVDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPEAKDHV
NSLGENLKTLRLRLRRCHRFLPCENKSKAVEQIKNAFNKLQEKGIYKAMSEFDIFINY
IEAYMTIKAR"
promoter 10076
/note="TATA: GATAAAA"
misc_feature complement(10148)
/note="polyA signal: AATAAA"
misc_feature 10173
/note="polyA signal: ATTAAA"
misc_feature 10257
/note="polyA signal: AATAAA, end of 0.8kb late RNA from
BCR1 and end of 1.6 kb late RNA, start unknown"
misc_feature complement(10277)
/note="polyA signal: AATAAA"
promoter complement(10975)
/note="TATA: CATAAAT"
promoter 11305
/note="TATA: TACAAAA; BCR2 promoter for highly spliced
EBNA latent RNAs."
mRNA 11336..11480
/note="exon C1 of Bodescot et al (1986) RNAs"
promoter 11524
/note="TATA: TATAATT"
misc_feature complement(11587)
/note="polyA signal: AATAAA"
promoter complement(11606)
/note="TATA: CATAAAT"
mRNA 11626..11657
/note="exon C2 of Bodescot et al (1986) RNAs"
promoter 11796
/note="TATA: TATAAGT"
promoter complement(11799)
/note="TATA: TATAAAA"
repeat_region 12001..15072
/note="3072 repeat 1"
CDS 12541..13689
/note="BCRF2 3072 repeat, reading frame 1; Author-given
protein sequence is in conflict with the conceptual
translation"
/codon_start=1
/db_xref="PID:e25077"
/db_xref="PID:g1334836"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 13215
/note="BAM: BamH1 C/W"
promoter 14352
/note="*TATA: TATAAAG BWR1 one of the promoters for highly
spliced EBNA and LP RNAs (Sample et al, 1986; Speck et al,
1986)"
mRNA 14384..14410
/note="*exon W0 of EBNA/LP RNAs"
mRNA 14554..14619
/note="*exon W1 (also W66) part of leader protein (LP)
gene. LP is also called EBNA-5 (Dillner et al, 1986) and
EBNA-4 (Rowe et al, 1987)."
mRNA 14559..14619
/note="*exon W1' (also W61) of EBNA/LP RNAs forms
initiator met when fused to exon W0 or exon C2."
mRNA 14701..14832
/note="*exon W2 (also W132) part of LP gene"
repeat_region 15073..18144
/note="3072 repeat 2"
CDS 15613..16761
/note="BWRF1 reading frame 2; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25078"
/db_xref="PID:g1334837"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 16287
/note="BAM: BamH1 W/W"
promoter 17424
/note="TATA: TATAAAG"
mRNA 17626..17691
/note="Exon W1"
mRNA 17773..17904
/note="Exon W2"
repeat_region 18145..21216
/note="3072 repeat 3"
CDS 18685..19833
/note="BWRF1 reading frame 3; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25079"
/db_xref="PID:g1334838"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 19359
/note="BAM: BamH1 W/W"
promoter 20496
/note="TATA: TATAAAG"
mRNA 20698..20763
/note="Exon W1"
mRNA 20845..20976
/note="Exon W2"
repeat_region 21217..24288
/note="3072 repeat 4"
CDS 21757..22905
/note="BWRF1 reading frame 4; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25080"
/db_xref="PID:g1334839"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 22431
/note="BAM: BamH1 W/W"
promoter 23568
/note="TATA: TATAAAG"
mRNA 23771..23835
/note="Exon W1"
mRNA 23917..24048
/note="Exon W2"
repeat_region 24289..27360
/note="3072 repeat 5"
CDS 24829..25977
/note="BWRF1 reading frame 5; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25081"
/db_xref="PID:g1334840"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 25503
/note="BAM: BamH1 W/W"
promoter 26640
/note="TATA: TATAAAG"
mRNA 26842..26907
/note="Exon W1"
mRNA 26989..27120
/note="Exon W2"
repeat_region 27361..30432
/note="3072 repeat 6"
CDS 27901..29049
/note="BWRF1 reading frame 6; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25066"
/db_xref="PID:g1334841"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 28575
/note="BAM: BamH1 W/W"
promoter 29712
/note="TATA: TATAAAG"
mRNA 29914..29979
/note="Exon W1"
mRNA 30061..30192
/note="Exon W2"
repeat_region 30433..33504
/note="3072 repeat 7"
CDS 30973..32121
/note="BWRF1 reading frame 7; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25067"
/db_xref="PID:g1334842"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 31647
/note="BAM: BamH1 W/W"
promoter 32784
/note="TATA: TATAAAG"
mRNA 32986..33051
/note="Exon W1"
mRNA 33133..33264
/note="Exon W2"
repeat_region 33505..36576
/note="3072 repeat 8"
CDS 34045..35193
/note="BWRF1 reading frame 8; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25068"
/db_xref="PID:g1334843"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 34719
/note="BAM: BamH1 W/W"
promoter 35856
/note="TATA: TATAAAG"
mRNA 36058..36123
/note="Exon W1"
mRNA 36205..36336
/note="Exon W2"
repeat_region 36577..39648
/note="3072 repeat 9"
CDS 37117..38265
/note="BWRF1 reading frame 9; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25069"
/db_xref="PID:g1334844"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 37791
/note="BAM: BamH1 W/W"
promoter 38928
/note="TATA: TATAAAG"
mRNA 39130..39195
/note="Exon W1"
mRNA 39277..39408
/note="Exon W2"
repeat_region 39649..42720
/note="3072 repeat 10"
CDS 40189..41337
/note="BWRF1 reading frame 10; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25070"
/db_xref="PID:g1334845"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 40863
/note="BAM: BamH1 W/W"
promoter 42000
/note="TATA: TATAAAG"
mRNA 42202..42267
/note="Exon W1"
mRNA 42349..42480
/note="Exon W2"
repeat_region 42721..45792
/note="3072 repeat 11"
CDS 43261..44409
/note="BWRF1 reading frame 11; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25071"
/db_xref="PID:g1334846"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 43935
/note="BAM: BamH1 W/W"
promoter 45072
/note="TATA: TATAAAG"
mRNA 45274..45339
/note="Exon W1"
misc_feature 45415..52824
/note="DEL: DAUDI deletion (Jones et al, 1984)"
mRNA 45421..45552
/note="Exon W2"
misc_feature 45644..52450
/note="DEL: P3HR1 deletion (Jeang and Hayward, 1983)"
repeat_region 45793..47643
/note="3072 repeat 12"
CDS 46333..47481
/note="BWRF1 reading frame 12; Author-given protein
sequence is in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25072"
/db_xref="PID:g1334847"
/translation="VWEAEGRPRPGEVEGDRPGLCWQSPGDPLRPSGPGRSPSAPQTD
PRVSRQGPASSGAAGSPPQAPQTRVSASRADRPRAWRLLGASRRGWFCPSLCPSEEPG
TSGTPEPLGPASRRPPGLRSPLSPVKPKECLRGATLGAQAPESRGQGHLRVPPRVPGQ
PEGPRQPGRPQRPVPRPFPGLQSPGCPPEGTLGVPSPPLQARASPSRRGASLGPQVQP
HRDPSGPDPPTGPSLCPPAPLQPSLHPRPQLLASPGPPGQPEGPRQPGRVAFPLPWPL
LPASHPSPLSLPPHRVHQAGRRDPGGPVSVPPAAAQSLPPGKGASFSPPSLRPSLLCT
VCKVQPPTPVHGSRAQPRPPLPTVDRPSVHPGHPRPPVSTPVPSRGDFM"
misc_feature 47007
/note="BAM: BamH1 W/Y"
mRNA 47761..47793
/note="Exon Y1 Bodescot et al, 1984"
promoter 47831
/note="TATA: TATAAGT"
mRNA 47878..47999
/note="Exon Y2 Bodescot et al, 1984 and EBNA-1 (Speck and
Strominger,1985), last common exon"
misc_feature complement(48023)
/note="polyA signal: AATAAA"
mRNA 48386..48444
/note="exon Bodescot et al, 1984"
CDS 48386..50032
/note="Coding exon for EBNA-2 (Sample et al,1986)"
/codon_start=1
/db_xref="PID:e25073"
CDS 48504..49967
/note="BYRF1, encodes EBNA-2 (Dambaugh et al, 1984;
Dillner et al, 1984)"
/codon_start=1
/db_xref="PID:e25074"
/db_xref="PID:g1632787"
/db_xref="SWISS-PROT:P12978"
/translation="MPTFYLALHGGQTYHLIVDTDSLGNPSLSVIPSNPYQEQLSDTP
LIPLTIFVGENTGVPPPLPPPPPPPPPPPPPPPPPPPPPPPPPPSPPPPPPPPPPPQR
RDAWTQEPSPLDRDPLGYDVGHGPLASAMRMLWMANYIVRQSRGDRGLILPQGPQTAP
QARLVQPHVPPLRPTAPTILSPLSQPRLTPPQPLMMPPRPTPPTPLPPATLTVPPRPT
RPTTLPPTPLLTVLQRPTELQPTPSPPRMHLPVLHVPDQSMHPLTHQSTPNDPDSPEP
RSPTVFYNIPPMPLPPSQLPPPAAPAQPPPGVINDQQLHHLPSGPPWWPPICDPPQPS
KTQGQSRGQSRGRGRGRGRGRGKGKSRDKQRKPGGPWRPEPNTSSPSMPELSPVLGLH
QGQGAGDSPTPGPSNAAPVCRNSHTATPNVSPIHEPESHNSPEAPILFPDDWYPPSID
PADLDESWDYIFETTESPSSDEDYVEGPSKRPRPSIQ"
repeat_region 48678..48800
/note="14 x CCCCCACCA repeats"
misc_feature 48848
/note="BAM: BamH1 Y/H"
promoter 49350
/note="TATA: TATAACA"
promoter complement(49353)
/note="TATA: TATAAAA"
repeat_region 49525..49578
/note="9 x GGGGCA repeats"
mRNA 49852..50032
/note="exon (Bodescot et al 1984)"
misc_feature 50003
/note="polyA signal: AATAAA, end of Bodescot T1 RNA and
EBNA-2 RNA (3.0kb latent RNA in IB4 cells)"
promoter complement(50156)
/note="TATA: TATAAGT"
misc_feature complement(50317)
/note="polyA signal: AATAAA, end of 2.5kb early RNA from
52817"
misc_feature complement(50578..52557)
/note="BHLF1 early reading frame"
repeat_region 50578..52115
/note="12 x 125bp repeats"
misc_feature 52654..53697
/note="region homologous to Eco R1 C of Raji"
promoter complement(52817)
/note="TATA: GATAAAA promoter for 2.5kb early RNA
containing BHLF1 (Jeang and Hayward, 1983; Freese et
al,1983)"
promoter 53759
/note="TATA: TATTAAC likely promoter for class III and IV
early RNAs encoding BHRF1 (Pearson et al, 1987)"
misc_feature 53895
/note="DONOR: CGGGTAACT donor for splice to 54335 in class
IV early RNAs encoding BHRF1 (Pearson et al, 1987)"
misc_feature 54335
/note="ACCEPT: TTTTCTAG acceptor from 48444 in class I,
47999 in class II, and 53895 in class IV early RNAs
encoding BHRF1 (Pearson et al, 1987)"
misc_feature 54376..54948
/note="BHRF1 reading frame, limited homolgy to bcl-2 gene.
Early gene in B95-8 cells and part of restricted EA
complex."
promoter 54591
/note="TATA: TATAACA"
promoter complement(54594)
/note="TATA: TATAAAT"
misc_feature 54853
/note="BAM: BamH1 H/F"
misc_feature complement(54929)
/note="polyA signal: AATAAA"
promoter complement(54977)
/note="TATA: TATAAAG"
misc_feature 55518
/note="polyA signal: AATAAA, 3' end of 2.5kb, 1.9kb, 1.7kb
and 0.6kb early RNAs"
misc_feature complement(55982..56935)
/note="BFLF2 reading frame, 4 NXT/S, homologous to RF 27
in VZV and HFRF2 in CMV"
misc_feature complement(55990)
/note="polyA signal: AATAAA, 3' end of 2.3kb and 1.1kb
early RNAs from 58568 and 57081"
promoter complement(56132)
/note="TATA: TATAAAG"
CDS complement(56948..58525)
/note="BFLF1 reading frame, 2 NXT/S homologous to RF 26 in
VZV and HFRF1 in CMV"
/codon_start=1
/db_xref="PID:g1334849"
/db_xref="SWISS-PROT:P03184"
/translation="MAHKVTSANEPNPLTGKRLSSCPLTRSGVTEVAQIAGRTPKMED
FVPWTVDNLKSQFEAVGLLMAHSYLPANAEEGIAYPPLVHTYESLSPASTCRVCDLLD
TLVNHSDAPVAFFEDYALLCYYCLNAPRAWISSLITGMDFLHILIKYFPMAGGLDSLF
MPSRILAIDIQLHFYICRCFLPVSSSDMIRNANLGYYKLEFLKSILTGQSPANFCFKS
MWPRTTPTFLTLPGPRTCKDSQDVPGDVGRGLYTALCCHLPTRNRVQHPFLRAEKGGL
SPEITTKADYCGLLLGTWQGTDLLGGPGHHAIGLNAEYSGDELAELALAITRPEAGDH
SQGPCLLAPMFGLRHKNASRTICPLCESLGAHPDAKDTLDRFKSLILDSFGNNIKILD
RIVFLIKTQNTLLDVPCPRLRAWLQMCTPQDFHKHLFCDPLCAINHSITNPSVLFGQI
YPPSFQAFKAALAAGQNLEQGVCDSLITLVYIFKSTQVARVGKTILVDVTKELDVVLR
IHGLDLVQSYQTSQVYV"
promoter complement(57081)
/note="TATA: TATTTAA before BFLF2; BFL2 promoter gives
1.1kb early RNA"
promoter complement(58088)
/note="TATA: GATAAAA"
promoter complement(58568)
/note="TATA: TATTAAA before BFLF1, BFL1 promoter gives
2.3kb early RNA"
promoter 58832
/note="TATA: TATAAAA before BFRF1"
CDS 58891..59901
/note="BFRF1 early reading frame, 1 NXT/S, homologous to
HFLF4 in CMV"
/codon_start=1
/db_xref="PID:g1334850"
/db_xref="SWISS-PROT:P03185"
/translation="MASPEERLLDELNNVIVSFLCDSGSLEVERCSGAHVFSRGSSQP
LCTVKLRHGQIYHLEFVYKFLAFKLKNCNYPSSPVFVISNNGLATTLRCFLHEPSGLR
SGQSGPCLGLSTDVDLPKNSIIMLGQDDFIKFKSPLVFPAELDLLKSMVVCRAYITEH
RTTMQFLVFQAANAQKASRVMDMISDMSQQLSRSGQVEDTGARVTGGGGPRPGVTHSG
CLGDSHVRGRGGWDLDNFSEAETEDEASYAPWRDKDSWSESEAAPWKKELVRHPIRRH
RTRETRRMRGSHSRVEHVPPETRETVVGGAWRYSWRATPYLARVLAVTAVALLLMFLR
WT"
CDS 59808..61583
/note="BFRF2 early reading frame, homologous to HFLF5 in
CMV"
/codon_start=1
/db_xref="PID:e25058"
/db_xref="PID:g1632788"
/db_xref="SWISS-PROT:P14347"
/translation="MALFLARHTLSGTGAGCHGRGPAPDVSEVDLTLQALGERGFSRL
LDLGLACLDLSYVEMREFVVWGRPPASEAAVASTPGSLFRSHSSAYWLSEVERPGGLV
RWARSQTSPSSLTLAPHLGPSLLSLSVVTGGGCGAVAFCNAFFLAYFLVVRSVFPAFS
DRIAAWICDRSPFCENTRAVARGYRGLVKRFLAFVFERSSYDPPLLRQNSRPVERCFA
IKNYVPGLDSQSCVTVPSFSRWAQSHASELDPREIRDRVTPATAPSFVADHASALLAS
LQKKASDTPCGNPIQWMWYRLLVNSCLRSAHCLLPIPAVSEGGRKTGGGVGEELVGAG
GPCLSRDVFVAIVSRNVLSCLLNVPAAGPRAYKCFRSHASRPVSGPDYPPLAVFCMDC
GYCLNFGKQTGVGGRLNSFRPTLQFYPRDQKEKHVLTCHASGRVYCSNCGSAAVGCQR
LAEPPSARSGWRPRIRAVLPHNAAYELDRGSRLLDAIIPCLGPDRTCMRPVVLRGVTV
RQLLYLTLRTEARAVCSICQQRQAPEDARDEPHLFSSCLEVELPPGERCAGCRLYQTR
YGTPAAQAHPPGEAGGGFSRQSPAS"
promoter complement(61062)
/note="TATA: GATAAAA"
promoter 61344
/note="TATA: TATTTAA before BFRF3"
CDS 61507..62037
/note="BFRF3 early reading frame"
/codon_start=1
/db_xref="PID:e25059"
/db_xref="PID:g1632789"
/db_xref="SWISS-PROT:P14348"
/translation="MARRLPKPTLQGRLEADFPDSPLLPKFQELNQNNLPNDVFREAQ
RSYLVFLTSQFCYEEYVQRTFGVPRRQRAIDKRQRASVAGAGAHAHLGGSSATPVQQA
QAAASAGTGALASSAPSTAVAQSATPSVSSSISSLRAATSGATAAASAAAAVDTGSGG
GGQPHDTAPRGARKKQ"
misc_feature complement(62068)
/note="polyA signal: AATAAA"
misc_feature 62069
/note="polyA signal: AATAAA, 3' end of 10, 6.5, 3.7, 3.4,
3.1, 2.5 and 0.8kb early RNAs"
CDS complement(62078..71527)
/note="BPLF1 reading frame, 1 NXT/S, analogous to VZV
RF22"
/codon_start=1
/db_xref="PID:g1334853"
/db_xref="SWISS-PROT:P03186"
/translation="MSNGDWGQSQRTRGTGPVRGIRTMDVNAPGGGSGGSALRILGTA
SCNQAHCKFGRFAGIQCVSNCVLYLVKSFLAGRPLTSRPELDEVLDEGARLDALMRQS
GILKGHEMAQLTDVPSSVVLRGGGRVHIYRSAEIFGLVLFPAQIANSAVVQSLAEVLH
GSYNGVAQFILYICDIYAGAIIIETDGSFYLFDPHCQKDAAPGTPAHVRVSTYAHDIL
QYVGAPGAQYTCVHLYFLPEAFETEDPRIFMLEHYGVYDFYEANGSGFDLVGPELVSS
DGEAAGTPGADSSPPVMLPFERRIIPYNLRPLPSRSFTSDSFPAARYSPAKTNSPPSS
PASAAPASAAPASAAPASAAPASAAPASAAPASAAPASAAPASSPPLFIPIPGLGHTP
GVPAPSTPPRASSGAAPQTPKRKKGLGKDSPHKKPTSGRRLPLSSTTDTEDDQLPRTH
VPPHRPPSAARLPPPVIPIPHQSPPASPTPHPAPVSTIAPSVTPSPRLPLQIPIPLPQ
AAPSNPKIPLTTPSPSPTAAAAPTTTTLSPPPTQQQPPQSAAPAPSPLLPQQQPTPSA
APAPSPLLPQQQPPPSAARAPSPLPPQQQPLPSATPAPPPAQQLPPSATTLEPEKNHP
PAADRAGTEISPSPPFGQQPSFGDDASGGSGLVRYLSDLEEPFLSMSDSEEAESDLAS
DIPTTEDEDMFEDEVFSNSLESGSSAPTSPITLDTARSQYYQTTFDIETPEMDFVPLE
SNIARIAGHTYQEQAIVYDPASNREVPEADALSMIDYLLVTVVLEQGLIRSRDRSSVL
NLLEFLKDWSGHLQVPTLDLEQLLTSELNIQNLANMLSENKGRAGEFHKHLAAKLEAC
LPSLATKDAVRVDAGAKMLAEIPQLAESDDGKFDLEAARRRLTDLLSGGDQEAGEGGG
EPEDNSIYRGPHVDVPLVLDDESWKRLLSLAEAARTAVARQQAGVDEEDVRFLALLTA
IEYGAPPAASVPPFVHNVAVRSKNAALHVRRCTADIRDKVASAASDYLSYLEDPSLPT
VMDFDDLLTHLRHTCQIIASLPLLNIRYTSIEWDYRELLYLGTALSDMSGIPWPLERV
EEDDPSIAPLPEFETVAKKQKELETTRENEKRLRTILDDIEAMLGLAGVASAPGAPIS
PASPSATPANHDNPEATPPLADTAALTIPVIEKYIANAGSIVGAAKNPTYIRLRDTIQ
QIVRSKKYLMNILKSITFYTIDNYIASFEESIDHLYRDLPVLDPEVQDGIDRILDPMV
SEALHTFEMGNRLTLEPARLVALQNFATHSTLKETAAAVNLLPGLLAVYDATITGQAP
EDALRLLSGLQNQLSQTLIPGKLKKRFLSYLQKLKNNNNDQLRQKEVQAWRLEAEGFK
PATEEQLEAFLDTAPNKELKRQYEKKLRQLMETGRKEKEKLREQEDKERQERRAREAN
EAWARIRKALGARPEPAPTSPDDWNTLLASLLPDNTDSAAAAAAAVARNTDILDSLTQ
ILAAMLLGITRVRRERLRSLLVDDGGAAERMEAAEPGWFTDIETGPLARLDAWPATPA
ATAKEGGGGRGAEEAAGALFRARTAADAIRSALAQTRQALQSPDMKSAVVNTDLEAPY
AEYERGLAGLLEKRRAAEAALTAIVSEYVDRTLPEATNDPGQANLPPPPTIPQATAPP
RLASDSALWPKKPQLLTRRERDDLLQATGDFFSELLTEAEAAEVRALEEQVRESQTLM
AKAHEMAASTRRGFHTALEAVLSRSRDEAPDDELRSLLPSPPKAPVQAPLEAALARAA
AGNGSWPYRKSLAAAKWIRGICEAVRGLSEGALALAGGAGAWLNLAAAADGEIHELTR
LLEVEGMAQNSMDGMEELRLALATLDPKRVAGGKETVADWKRRLSRLEAIIQEAQEES
QLQGTLQDLVTQARGHTDPRQLKIVVEAARGLALGASAGSQYALLKDKLLRYASAKQS
FLAFYETAQPTVFVKHPLTNNLPLLITISAPPTGWGNGAPTRRAQFLAAAGPAKYAGT
LWLETESPCDPLNPAYVSADTQEPLNYIPVYHNFLEYVMPTVLENPEAFSLTPAGRPQ
AIGPPQDDQERRRRTLASVASARLSAAAADSYWDTWPDVESNAGELLREYVSAPKALM
EDLADNPIVAMTLLAHASLIASRNHPPYPAPATDREVILLEQREMMALLVGTHPAYAA
AFLGAPSFYAGLGLVSALARDGGLGDLLSDSVLTYRLVRSPASGRGGMPSTTRGSNDG
EDARRLTRHRIAGPPTGFIFFQDAWEEMDTRAALWPHPEFLGLVHNQSTARARACMLL
LARRCFAPEALQQLWHSLRPLEGPVAFQDYLRDFVKQAYTRGEELPRAEGLEVPRETP
SSYGTVTGRALRNLMPYGTPITGPKRGSGDTIPVSVFEAAVAAAFLGRPLTLFVSSQY
LFNLKTLGQVRVVAPLLYCDGHSEPFRSLVETISLNFLQDLDGYSESFEPEMSIFARQ
AVWLRELLTEARAAKPKEARPPTVAILANRKNIIWKCFTYRHNLPDVQFYFNAAGASR
WPTDVLNPSFYEHEDPPLPVGYQLPPNPRNVQELFSGFPPRVGHGLVSGDGFQSADNT
PASSDRLQQLGGGETDQGEKGSTTAESEASGPPSPQSPLLEKVAPGRPRDWLSPTSSP
RDVTVTPGLAAPITLPGPRLMARPYFGAETRASESPDRSPGSSPRPWPKDSLELLPQP
APQQPPSSPWASEQGPIVYTLSPHSTPSTASGSQKKHTIQIPGLVPSQKPSYPPSAPY
KPGQSTGGIAPTPSAASLTTFGLQPQDTQASSQDPPYGHSIMQREKKQQGGREEAAEI
RPSATRLPTAVGLRPRAPVVAAGAAASATPAFDPGEAPSGFPIPQAPALGSGLAAPAH
TPVGALAPRPQKTQAQRPQDAAALPTPTIKAVGARPVPKATGALAAGARPRGQPTAAP
PSAASPPRVSLPVRSRQQQSPAIPLPPMHSGSEPGARPEVRLSQYRHAGPQTYTVRKE
APPSAASQLPKMPKCKDSMYYPPSGSARYPAPFQALSFSQSVASPAPSSDQTTLLWNT
PSVVTQFLSIEDIIREVVTGGSTSGDLVVPSGSPSSLSTAAPEQDLRYSLTLSQASRV
LSRFVSQLRRKLERSTHRLIADLERLKFLYL"
misc_feature 62249
/note="BAM: BamH1 F/Q"
misc_feature 62430..62477
/note="Site III for EBNA-1 binding (Rawlins et al, 1985)"
misc_feature 66121
/note="BAM: BamH1 Q/U"
mRNA 67477..67649
/note="Exon in EBNA-1 RNA (Speck and Strominger,1985) and
cDNA clone T4 (Bodescot et al, 1986)"
misc_feature 69410
/note="BAM: BamH1 U/P"
repeat_region 69684..69930
/note="5 x 51bp repeats"
repeat_region 70387..70521
/note="9 x 15bp repeat"
promoter 70750
/note="TATA: CATAAAA"
CDS complement(71520..75239)
/note="BOLF1 reading frame, 1 NXT/S analogous to VZV RF
21"
/codon_start=1
/db_xref="PID:g1334855"
/db_xref="SWISS-PROT:P03189"
/translation="MASAMESDSSGGSGGADAQPPLAEVDGGLARVTRQLLLSGDDPA
ARLRALMPLELGIFGLGDLAQPVLVRDFLNTLTLMSGHAYPAAVLRHHAYYLLRAASF
SRRSFGLGHLEAALDVLASSLPPTTASPATDDPLDGSRLIAETRALAAAYRRIIEEGS
GEVLAVSGPTATFAFVEELVADTYLARWDAFPREGLSFYAFNAAKTTLGRWLVTVYAE
TNRYPWAAAGQGQPTAADIKAMAVELVEHSGGGAGGGEGEESGGGLFHRPESLSSVVA
SLPLARRRAVEILGVYAEASGGQTPPVAAVPVLAFDAARLRLLEPSGALFYDYVYEAL
LWDQTYGVPDSVIEAFLAGMAAEMEALAARVQEAAGSRASFSPAAIEQVATVLLSAGL
NETVAGDYAMMLASVPRVSRSRWRWLEATAALLESLSGFALHFFRLLPTASPTSRFAR
VARAAYLRAEAEAVDRRARRTSGPSTPAAAPAATAVGVGAAADPWDAVTPLRIFIVPP
PAAEYEQVAGDLSSELLRSLLWVRYSRLWQAPAPAPALPCKPPLLPGEQGRRQWTAAV
AAAPRTDVEAYCRSLRAGQTARADPAYVHSPFFPAAFIEFQIWPALRRVLSNELPKTR
SLAALRWLVSFGSDLALPSPELTRARRPLELIYATVWEIYDGAPPMPGESPQAVGLRP
LNLEGEGKAGDAGAEGAEDEEGGGPWGLSSHDAVLRIMDAVREVSGIISETISASERA
AEAPPLAWPTSLFSLLFTLRYSTTAESLGLATRRFLVSGETLSEDISRLTGAAWRLCS
RPLLYDAETGRVQIPLATEEEEEAVVAVKEKSVSSSPRHYSTDLQTLKSVVEGIQDVC
RDAAARWALATADTATLRRRLLVPALRESRGIADHPLWAHTSEPLRPDLEELNERVEH
ALELGYSLTGALRRSVAYRFRDYTFARLFQPPAIDAERAEAIVRRDARPPPVFIPAPR
RLPQGGADTPPPLSMDDILYLGKSICKALVDVLDHHPAAPETTPIKTYTPAMDLNPEQ
ITVTPRSPSVLAAFARTARVQTHHLVPALTDDSPSPVGQTPPPFRILPAKKLAAILLG
NGRNASKRRASRDLSPPPHGRWRAVLDSSPFSFSSSDFSDQDEGEGGEADLRGVPGGG
GEGAYEEDRERPSDIDTAARAQKVETSCPRRRSPRTTPSPSRRASGGGGPDRGEAEAH
TYPPYLSAAAAASRVRPRTRRGATRRPPRPTAEDE"
promoter complement(72192)
/note="TATA: TATTAAA before BPLF1"
misc_feature 73468
/note="BAM: BamH1 P/O"
promoter 75017
/note="TATA: TATTTAA BO-R1 late promoter before BORF1,
gives 3.9kb late RNA"
CDS 75238..76332
/note="BORF1 late reading frame, 2 NXT/S homologous to VZV
RF20"
/codon_start=1
/db_xref="PID:g1334854"
/db_xref="SWISS-PROT:P03187"
/translation="MKVQGSVDRRRLQRRIAGLLPPPARRLNISRGSEFTRDVRGLVE
EHAQASSLSAAAVWRAGLLAPGEVAVAGGGSGGGSFSWSGWRPPVFGDFLIHASSFNN
AEATGTPLFQFKQSDPFSGVDAVFTPLSLFILMNHGRGVAARVEAGGGLTRMANLLYD
SPATLADLVPDFGRLVADRRFHNFITPVGPLVENIKSTYLNKITTVVHGPVVSKAIPR
STVKVTVPQEAFVDLDAWLSGGAGGGGGVCFVGGLGLQPCPADARLYVALTYEEAGPR
FTFFQSSRGHCQIMNILRIYYSPSIMHRYAVVQPLHIEELTFGAVACLGTFSATDGWR
RSAFNYRGSSLPVVEIDSFYSNVSDWEVIL"
promoter complement(75322)
/note="TATA: TATTTAG before BOLF1"
promoter 75819
/note="TATA: TATAAAG"
misc_feature 75838
/note="polyA signal: AATAAA"
misc_feature complement(76126)
/note="polyA signal: AATAAA"
promoter 76169
/note="TATA: TACATAT BO-R2 early promoter before BORF2,
gives 2.8kb RNA"
misc_feature complement(76300)
/note="polyA signal: AATAAA"
CDS 76407..78887
/note="BORF2 early reading frame, 2 NXT/S. Homology HSV
140K ribonucleotide reductase (Gibson et al, 1984) and RF
19 VZV"
/codon_start=1
/db_xref="PID:g1334856"
/db_xref="SWISS-PROT:P03190"
/translation="MATTSHVEHELLSKLIDELKVKANSDPEADVLAGRLLHRLKAES
VTHTVAEYLEVFSDKFYDEEFFQMHRDELETRVSAFAQSPAYERIVSSGYLSALRYYD
TYLYVGRSGKQESVQHFYMRLAGFCASTTCLYAGLRAALQRARPEIESDMEVFDYYFE
HLTSQTVCCSTPFMRFAGVENSTLASCILTTPDLSSEWDVTQALYRHLGRYLFQRAGV
GVGVTGAGQDGKHISLLMRMINSHVEYHNYGCKRPVSVAAYMEPWHSQIFKFLETKLP
ENHERCPGIFTGLFVPELFFKLFRDTPWSDWYLFDPKDAGDLERLYGEEFEREYYRLV
TAGKFCGRVSIKSLMFSIVNCAVKAGSPFILLKEACNAHFWRDLQGEAMNAANLCAEV
LQPSRKSVATCNLANICLPRCLVNAPLAVRAQRADTQGDELLLALPRLSVTLPGEGAV
GDGFSLARLRDATQCATFVVACSILQGSPTYDSRDMASMGLGVQGLADVFADLGWQYT
DPPSRSLNKEIFEHMYFTALCTSSLIGLHTRKIFPGFKQSKYAGGWFHWHDWAGTDLS
IPREIWSRLSERIVRDGLFNSQFIALMPTSGCAQVTGCSDAFYPFYANASTKVTNKEE
ALRPNRSFWRHVRLDDREALNLVGGRVSCLPEALRQRYLRFQTAFDYNQEDLIQMSRD
RAPFVDQSQSHSLFLREEDAARASTLANLLVRSYELGLKTIMYYCRIEKAADLGVMEC
KASAALSVPREEQNERSPAEQMPPRPMEPAQVAGPVDIMSKGPGEGPGGWCVPGGLEV
CYKYRQLFSEDDLLETDGFTERACESCQ"
misc_feature 77835
/note="BAM: Bam H1 O/a"
promoter 78804
/note="TATA: TATAAGT Ba-R1 early promoter before BaRF1,
gives 3.5kb RNA"
misc_feature 78883
/note="polyA signal: AATAAA, end of 3.9kb late RNA from
75017 and 2.8kb early RNA from 76169"
misc_feature complement(78896)
/note="polyA signal: AATAAA"
CDS 78900..79808
/note="BaRF1 early reading frame, homologous to HSV 38K
ribonucleotide reductase (Gibson et al, 1984) and RF 18
VZV"
/codon_start=1
/db_xref="PID:g1334857"
/db_xref="SWISS-PROT:P03175"
/translation="MSKLLYVRDHEGFACLTVETHRNRWFAAHIVLTKDCGCLKLLNE
RDLEFYKFLFTFLAMAEKLVNFNIDELVTSFESHDIDHYYTEQKAMENVHGETYANIL
NMLFDGDRAAMNAYAEAIMADEALQAKISWLRDKVAAAVTLPEKILVFLLIEGIFFIS
SFYSIALLRVRGLMPGICLANNYISRDELLHTRAASLLYNSMTAKADRPRATWIQELF
RTAVEVETAFIEARGEGVTLVDVRAIKQFLEATADRILGDIGQAPLYGTPPPKDCPLT
YMTSIKQTNFFEQESSDYTMLVVDDL"
promoter complement(79495)
/note="TATA: TATAACA"
misc_feature 79537
/note="BAM: Bam H1 a/M"
promoter 79840
/note="TATA: CATAAAT BM-R1 early promoter before BMRF1,
gives 2.5kb RNA"
CDS 79899..81113
/note="BMRF1 early reading frame. Early antigen protein
recognised by R3 monoclonal (Pearson et al 1983; Cho et
al, 1985a)"
/codon_start=1
/db_xref="PID:g1334858"
/db_xref="SWISS-PROT:P03191"
/translation="METTQTLRFKTKALAVLSKCYDHAQTHLKGGVLQVNLLSVNYGG
PRLAAVANAGTAGLISFEVSPDAVAEWQNHQSPEEAPAAVSFRNLAYGRTCVLGKELF
GSAVEQASLQFYKRPQGGSRPEFVKLTMEYDDKVSKSHHTCALMPYMPPASDRLRNEQ
MIGQVLLMPKTASSLQKWARQQGSGGVKVTLNPDLYVTTYTSGEACLTLDYKPLSVGP
YEAFTGPVAKAQDVGAVEAHVVCSVAADSLAAALSLCRIPAVSVPILRFYRSGIIAVV
AGLLTSAGDLPLDLSVILFNHASEEAAASTASEPEDKSPRVQPLGTGLQQRPRHTVSP
SPSPPPPPRTPTWESPARPETPSPAIPSHSSNTALERPLAVQLARKRTSSEARQKQKH
PKKVKQAFNPLI"
promoter 80779
/note="TATA: TATTTAA BM-R2 late promoter before BMRF2"
misc_feature complement(80782)
/note="polyA signal: AATAAA"
promoter 80832
/note="TATA: GATAAAA, possible promoter for 1.4kb late RNA
encoding BMRF2"
CDS 81118..82191
/note="BMRF2 early reading frame"
/codon_start=1
/db_xref="PID:g1334859"
/db_xref="SWISS-PROT:P03192"
/translation="MFSCKQHLSLGACVFCLGLLASTPFIWCFVFANLLSLEIFSPWQ
THVYRLGFPTACLMAVLWTLVPAKHAVRAVTPAIMLNIASALIFFSLRVYSTSTWVSA
PCLFLANLPLLCLWPRLAIEIVYICPAIHQRFFELGLLLACTIFALSVVSRALEVSAV
FMSPFFIFLALGSGSLAGARRNQIYTSGLERRRSIFCARGDHSVASLKETLHKCPWDL
LAISALTVLVVCVMIVLHVHAEVFFGLSRYLPLFLCGAMASGGLYLGHSSIIACVMAT
LCTLTSVVVYFLHETLGPLGKTVLFISIFVYYFSGVAALSAAMRYKLKKFVNGPLVHL
RVVYMCCFVFTFCEYLLVTFIKS"
promoter 81751
/note="TATA: CATAAAT"
misc_feature 82180
/note="polyA signal: ATTAAA, end of 3.5kb early RNA from
78804, 2.5kb early RNA from 79840 and 1.4kb late RNA"
promoter complement(82311)
/note="TATA: CATAAAT"
repeat_region 82319..82461
/note="2x71bp repeats"
CDS complement(82743..84059)
/note="BMLF1 early reading frame. Diffuse early antigen
(Cho et al, 1985b). Also homologous to RF 4 VZV and IE63
of HSV.(BSLF2 + BMLF1) is also called EB2
(Chevallier-Greco et al, 1986). General transactivator of
transcription (Lieberman et al, 1986)."
/codon_start=1
/db_xref="PID:e25042"
/db_xref="PID:g1632790"
/db_xref="SWISS-PROT:Q04360"
/translation="MEGSEEHSTDGEISSSEEEDEDPTPAHAIPARPSSVVITPTSAS
FVIPRKKWDLQDKTVTLHRSPLCRDEDEKEETGNSSYTRGHKRRRGEVHGCTDESYGK
RRHLPPGARAPRAPRAPRVPRAPRSPRAPRSNRATRGPRSESRGAGRSTRKQARQERS
QRPLPNKPWFDMSLVKPVSKITFVTLPSPLASLTLEPIQDPFLQSMLAVAAHPEIGAW
QKVQPRHELRRSYKTLREFFTKSTNKDTWLDARMQAIQNAGLCTLVAMLEETIFWLQE
ITYHGDLPLAPAEDILLACAMSLSKVILTKLKELAPCFLPNTRDYNFVKQLFYITCAT
ARQNKVVETLSSSYVKQPLCLLAAYAAVAPAYINANCRRRHDEVEFLGHYIKNYNPGT
LSSLLTEAVETHTRDCRSASCSRLVRAILSPGTGSLGLFFVPGLNQ"
misc_feature complement(82747)
/note="polyA signal: AATAAA"
repeat_region 83640..83729
/note="10x9bp repeats"
misc_feature complement(84122)
/note="ACCEPT: CTCCCCTCTGCAG acceptor in spliced form of
BMLF1 RNA"
misc_feature complement(84227)
/note="DONOR: CAGGTAAGA donor in spliced form of BMLF1
RNA"
CDS complement(84229..84288)
/note="BSLF2 early reading frame in 5' exon of spliced RNA
encoding BMLF1"
/codon_start=1
/db_xref="PID:g1334861"
/translation="MVPSQRLSRTSSISSNEDPA"
misc_feature 84233
/note="BAM: Bam H1 M/S"
CDS complement(84257..86881)
/note="BSLF1 reading frame, homologous to RF 6 VZV"
/codon_start=1
/db_xref="PID:g1334862"
/db_xref="SWISS-PROT:P03193"
/translation="MSAPVVIKALVASNTDIAEAILDAILSRPDEGFRLFCLCHNASP
LHHVAGSLVELQLHLPKKRLTSQSRCGLVLTLHLPAEEAFPFLRGLTPLTADRLSTYL
DRAGALRSLTPLVELLTLSAKKQPQGDARGRVAWLRPKIVGCLRRIYRVNISARWFIS
TFGSHEAQFVLVTAAYYFWGIPCTIETLAHLTELFTSESGQSLAAVTSLAELGEVFGS
SAWAEQTEAFAHFAHEKLRRDSREIRAVARTIDAYRGRLPLASADLVRYVYLAHAQCF
NEGTFKRYSQLTSMGEIGCLPSGGVVLPSLLDRGFAEHMRTYFTRETYLAEHVRVQQL
KIRMEPPAPYTWDPDPDDGLMRAWAGLSVDVARELVELARWHADEGPTYPPTLQGFLC
LAGQATCRGQWNPKEQFLPPTVLRRVQRLPVFLCHFADRHYFVMTAADPFSSHLAEVV
STPTNCRLPDTCLTRALSYTPVYYSQNSLSEQLFVSRHEYFNPRLPVCNLVLDLDLKI
KGAPWSLEEIYDLCRTVRREVLRLMRRLGPVSRAHPVYFFKSACPPADPDNMEDVLPF
CICTGKLGFRVITPLPRGHAIVGTSAVQGFVSVLQKLMGLTACLRRMRHKIKEIGAPL
FDSGVYHAGRCIRLPHTYKVDRGGGLSRQLRLFVCHPEEEDKHSYVKNALNIQNLLHH
SLHVGWPAPKTFCYHIADDGRDYLIQRTRETLPPTVENVCAMIEGHLGLDLVAWVSSC
IWPSLMSTLATAVPEDKFPQFLHVTFEQTGPNLVQVCHARGRNFACLRHTHRASSKNV
RVFLVLYYTSQAITVTFMSQCFAGRCGANQPTAHFSISVPASRIINRAEASQDSTTSQ
LARRRDRQDGSFSETLPN"
promoter complement(84356)
/note="TATA: CATAAAT before BSLF2 and BMLF1. Two RNAs
start here; one is spliced and the other is unspliced,
both traverse BMLF1."
promoter 86882
/note="TATA: TATTTAA BS-R1 late promoter before BSRF1"
CDS 86924..87580
/note="BSRF1 reading frame"
/codon_start=1
/db_xref="PID:g1334863"
/db_xref="SWISS-PROT:P03194"
/translation="MAFYLPDWSCCGLWLFGRPRNRYSQLPEEPETFECPDRWRAEID
LGLPPGVQVGDLLRNEQTMGSLRQVYLLAVQANSITDHLKRFDAVRVPESCRGVVEAQ
VAKLEAVRSVIWNTMISLAVSGIEMDENGLKALLDKQAGDSLALMEMEKVATALKMDE
TGAWAQEISAVVSSVTAPSASAPFINSAFEPEVPTPVLAPPPVVRQPEHSGPTELALT
"
misc_feature complement(87134)
/note="polyA signal: AATAAA"
misc_feature 87599
/note="polyA signal: AATAAA"
misc_feature complement(87613)
/note="polyA signal: AATAAA, end 1.0kb early RNA from
BLL3"
CDS complement(87638..88474)
/note="BLLF3 early reading frame (BLLF2 in Baer et al,
1984). Homologous to RF 8 VZV and dUTPase HSV."
/codon_start=1
/db_xref="PID:g1334864"
/db_xref="SWISS-PROT:P03195"
/translation="MEACPHIRYAFQNDKLLLQQASVGRLTLVNKTTILLRPMKTTTV
DLGLYARPPEGHGLMLWGSTSRPVTSHVGIIDPGYTGELRLILQNQRRYNSTLRPSEL
KIHLAAFRYATPQMEEDKGPINHPQYPGDVGLDVSLPKDLALFPHQTVSVTLTVPPPS
IPHHRPTIFGRSGLAMQGILVKPCRWRRGGVDVSLTNFSDQTVFLNKYRRFCQLVYLH
KHHLTSFYSPHSDAGVLGPRSLFRWASCTFEEVPSLAMGDSGLSEALEGRQGRGFGSS
GQ"
misc_feature 87650
/note="BAM: Bam H1 S/L"
promoter 88507
/note="TATA: TATATAT BL-R1 late promoter before BLRF1,
gives 1.0kb late RNA"
promoter 88511
/note="TATA: TATAAGA"
promoter complement(88514)
/note="TATA: TATATAT BL-L3 early promoter before BLLF3,
gives 1.0kb early RNA"
CDS 88547..88855
/note="BLRF1 late reading frame"
/codon_start=1
/db_xref="PID:g1334865"
/db_xref="SWISS-PROT:P03196"
/translation="MGKVLRKPFAKAVPLLFLAATWLLTGVLPAGASSPTNAAAASLT
EAQDQFYSYTCNADTFSPSLTSFASIWALLTLVLVIIASAIYLMYVCFNKFVNTLLTD
"
promoter 88863
/note="TATA: TATTTAA BL-R2 late promoter before BLRF2,
gives 0.6kb late RNA"
CDS 88925..89413
/note="BLRF2 late reading frame, 2 NXS/T"
/codon_start=1
/db_xref="PID:g1334866"
/db_xref="SWISS-PROT:P03197"
/translation="MSAPRKVRLPSVKAVDMSMEDMAARLARLESENKALKQQVLRGG
ACASSTSVPSAPVPPPEPLTARQREVMITQATGRLASQAMKKIEDKVRKSVDGVTTRN
EMENILQNLTLRIQVSMLGAKGQPSPGEGTRPRESNDPNATRRARSRSRGREAKKVQI
SD"
misc_feature 89412
/note="polyA signal: AATAAA, end of 1.0kb and 0.6kb late
RNAs"
misc_feature complement(89425)
/note="polyA signal: AATAAA, end of 0.7kb early, 2.2kb
late and 2.8kb late RNA"
CDS complement(89430..92153)
/note="BLLF1a, late reading frame, gp350 membrane antigen,
36 NXT /S (Hummel et al, 1984; Biggin et al, 1984; Beisel
et al, 1985)"
/codon_start=1
/db_xref="PID:g1334869"
/db_xref="SWISS-PROT:P03200"
/translation="MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTA
DVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGEL
ALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYI
KWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEI
SQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLG
NNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVP
MVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDIT
VSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPS
STHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTS
STSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPT
PNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQAN
ATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSD
NSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTST
KPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTE
PTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRF
SNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV"
CDS complement(89430..92153)
/note="BLLF1b, late reading frame gp220 membrane antigen,
spliced form of BLLF1a (Hummel et al, 1984; Biggin et al,
1984; Beisel et al, 1985)"
/codon_start=1
/db_xref="PID:g1334868"
/db_xref="SWISS-PROT:P03200"
/translation="MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTA
DVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGEL
ALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYI
KWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEI
SQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLG
NNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVP
MVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDIT
VSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPS
STHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTS
STSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPT
PNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQAN
ATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSD
NSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTST
KPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTE
PTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRF
SNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV"
promoter complement(89434)
/note="TATA: TATAAAG"
CDS complement(89567..90013)
/note="BLLF2 early reading frame (BLLF3 in Baer et al,
1984)"
/codon_start=1
/db_xref="PID:g1334867"
/db_xref="SWISS-PROT:P03199"
/translation="MCPPVRQHPAQAPPAKRQALETVPHPQNRGRLMSPKARPPKMQR
RPRPPVAKRRRFPRSPQQVERPILPPVESTPQDMEPGQVQSPPQITAVIQLRQDRDTM
RPPIYLPALLANCGPAGLLRAHRLPQPKPPCQSRQRPSPDSQTSPC"
promoter complement(90051)
/note="TATA: TATAACA BL-L2 early promoter before BLLF2,
gives 0.7kb early RNA"
intron complement(90062..90652)
/note="intervening sequence in gp220 gene"
repeat_region 90177..90639
/note="21 copies of 21bp approximate repeat"
promoter complement(92192)
/note="TATA: TATTAAA BL-L1 late promoter before BLLF1a,b.
Gives 2.8 and 2.2kb late RNAs"
mRNA 92238..92581
/note="Exon in Bodescot et al (1986) RNA (spliced from
20763 to 92670)"
CDS 92243..92602
/note="BLRF3 reading frame"
/codon_start=1
/db_xref="PID:g1632791"
/db_xref="SWISS-PROT:P03202"
/translation="MDKDRPGPPALDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDS
SSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPMLPPQPDLPGREAILRRFPLDLR
TLLQAIGAAATVSIPMA"
CDS 92670..95162
/note="BERF1 frame, homology with BERF2b and BERF4. A
fusion of BLRF3 with BERF1 encodes EBNA-3A, latent cycle
gene. (Hennessy et al, 1986, Joab et al, 1987);
Author-given protein sequence is in conflict with the
conceptual translation"
/codon_start=1
/db_xref="PID:e25053"
/db_xref="PID:g1334871"
/translation="RIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRD
QAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAG
TFKLPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQR
VSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQAWNAGFLRGRAY
GIDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHR
LLLMRAGKRTEQGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPP
TIHLAAQGMAYPLHEQHGMAPCPVAQAPPTPLPPVSPGDQLPGVFSDGRVACAPVPAP
AGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERPVYPKPVRPAPPKIAM
QGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQ
LTQVSPQQPMEGPLVPEQQMFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGA
PVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVPEQWMFP
GAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPS
QGTDVVQHQLDALGYTLHGLNHPGVPVSPAVNQYHLSQAAFGLPIDEDESGEGSDTSE
PCEALDLSIHGRPCPQAPEWPVQEEGGQDATEVLDLSIHGRPRPRTPEWPVQGEGGQN
VTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA"
mRNA 92670..95248
/note="Exon in (Bodescot et al, 1986) RNA from 92581, to
3' end"
misc_feature 92703
/note="BAM: Bam H1 L/E"
promoter complement(93161)
/note="TATA: CATAAAT"
promoter 93479
/note="TATA: TATAAGA"
promoter complement(93482)
/note="TATA: TATAAAT"
repeat_region 94208..94277
/note="repeat type A"
repeat_region 94281..94306
/note="repeat type B"
repeat_region 94307..94381
/note="repeat type C"
repeat_region 94386..94411
/note="repeat type B"
repeat_region 94412..94489
/note="repeat type C"
repeat_region 94490..94560
/note="repeat type A"
repeat_region 94571..94648
/note="repeat type C"
repeat_region 94649..94719
/note="repeat type A"
repeat_region 94896..94982
/note="repeat type D"
repeat_region 94983..95069
/note="repeat type D"
misc_feature 95221
/note="polyA signal: AATAAA"
misc_feature complement(95272)
/note="polyA signal: AATAAA"
CDS join(95353..95709,95788..98247)
/codon_start=1
/product="EBNA3B (EBNA4A) latent protein"
/db_xref="PID:e276431"
/db_xref="PID:g1632792"
/translation="MKKAWLSRAQQADAGGASGSEDPPDYGDQGNVTQVGSEPISPEI
GPFELSAASEDDPQSGPVEENLDAAAREEEEPHEQEHNGGDDPLDVHTRQPRFVDVNP
TQAPVIQLVHAVYDSMLQSDLRPLGSLFLEQNLNIEEFIWMCMTVRHRCQAIRKKPLP
IVKQRRWKLLSSCRSWRMGYRTHNLKVNSFESGGDNVHPVLVTATLGCDEGTRHATTY
SAGIVQIPRISDQNQKIETAFLMARRARSLSAERYTLFFDLVSSGNTLYAIWIGLGTK
NRVSFIEFVGWLCKKDHTHIREWFRQCTGRPKAAKPWLRAHPVAIPYDDPLTNEEIDL
AYARGQAMNIEAPRLPDDPIIVEDDDESEEIEAESDEEEDKSGMESLKNIPQTLPYNP
TVYGRPAVFDRKSDAKSTKKCRAIVTDFSVIKAIEEEHRKKKAARTEQPRATPESQAP
TVVLQRPPTQQEPGPVGPLSVQARLEPWQPLPGPQVTAVLLHEESMQGVQVHGSMLDL
LEKDDEVMEQRVMATLLPPVPQQPRAGRRGPCVFTGDLGIESDEPASTEPVHDQLLPA
PGPDPLEIQPLTSPTTSQLSSSAPSCAQTPWPVVQPSQTPDDPTKQSRPPETAAPRQW
PMPLRPIPMRPLRMQPIPFNHPVGPTPHQTPQVEITPYKPTWAQIGHIPYQPTPTGPA
TMLLRQWAPATMQTPPRAPTPMSPPEVPPVPRQRPRGAPTPTPPPQVPPVPRQRPRGA
PTPTPPPQVLPTPMQLALRAPAGQQGPTKQILRQLLTGGVKKGRPSLKLQAALERQAA
AGWQPSPGSGTSDKIVQAPIFYPPVLQPIQVMGQGGSPTAMAASAVTQAPTEYTRERR
GVGPMPPTDIPPSKRAKIEAYTEPEMPHGGASHSPVVILENVGQGQQQTLECGGTAKQ
ERDMLGLGDIAVSSPSSSETSNDE"
mat_peptide 95353..95724
/note="BERF2a reading frame"
mat_peptide 95725..98244
/note="BERF2b frame, homology with BERF1 and BERF4. BERF2a
and BERF2b are spliced together to make EBNA3B (EBNA4A)
latent protein."
misc_feature complement(95819)
/note="polyA signal: AATAAA"
promoter complement(95853)
/note="TATA: TATAAAT"
misc_feature complement(96276)
/note="polyA signal: AATAAA"
repeat_region 97522..97698
/note="3x60bp repeat"
mat_peptide 98323..98769
/note="BERF3 reading frame"
mRNA 98364..98730
/note="Exon in EBNA-1 RNA (Speck and Strominger, 1985)"
CDS join(98371..98730,98805..101423)
/codon_start=1
/product="EBNA3C (EBNA 4B) latent protein"
/db_xref="PID:e276455"
/db_xref="PID:g1632793"
/translation="MESFEGQGDSRQSPDNERGDNVQTTGEHDQDPGPGPPSSGASER
LVPEESYSRDQQPWGQSRGDENRGWMQRIRRRRRRRAALSGHLLDTEDNVPPWLPPHD
ITPYTARNIRDAACRAVKQSHLQALSNLILDSGLDTQHILCFVMAARQRLQDIRRGPL
VAEGGVGWRHWLLTSPSQSWPMGYRTATLRTLTPVPNRVGADSIMLTATFGCQNAART
LNTFSATVWTPPHAGPREQERYAREAEVRFLRGKWQRRYRRIYDLIELCGSLHHIWQN
LLQTEENLLDFVRFMGVMSSCNNPAVNYWFHKTIGNFKPYYPWNAPPNENPYHARRGI
KEHVIQNAFRKAQIQGLSMLATGGEPRGDATSETSSDEDTGRQGSDVELESSDDELPY
IDPNMEPVQQRPVMFVSRVPAKKPRKLPWPTPKTHPVKRTNVKTSDRSDKAEAQSTPE
RPGPSEQSSVTVEPAHPTPVEMPMVILHQPPPVPKPVPVKPTPPPSRRRRGACVVYDD
DVIEVIDVETTEDSSSVSQPNKPHRKHQDGFQRSGRRQKRAAPPTVSPSDTGPPAVGP
PAAGPPAAGPPAAGPPAAGPPAAGPPAAGPRILAPLSAGPPAAGPHIVTPPSARPRIM
APPVVRMFMRERQLPQSTGRKPQCFWEMRAGREITQMQQEPSSHLQSATQPTTPRPSW
APSVCALSVMDAGKAQPIESSHLSSMSPTQPISHEEQPRYEDPDAPLDLSLHPDVAAQ
PAPQAPYQGYQEPPAPQAPYQGYQEPPPPQAPYQGYQEPPAHGLQSSSYPGYAGPWTP
RSQHPCYRHPWAPWSQDPVHGHTQGPWDPRAPHLPPQWDGSAGHGQDQVSQFPHLQSE
TGPPRLQLSLVPLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSMAVGCDSSGTA
CPSMPFASDYSQGAFTPLDINATTPKRPRVEESSHGPARCSQATAEAQEILSDNSEIS
VFPKDAKQTDYDASTESELD"
misc_feature 98731
/note="DONOR: AAGGTGAGT donor"
mat_peptide 98805..101420
/note="BERF4 frame, homology with BERF1 and BERF2b. BERF3
and BERF4 are spliced together to make the EBNA3C (EBNA
4B) latent protein."
mRNA 98805..99050
/note="Exon in T4 cDNA (Bodescot et al 1986). 99050 is not
the end of the RNA."
misc_feature 99126..102118
/note="DEL: Deletion in Raji"
promoter 99443
/note="TATA: CATAAAA"
misc_feature 100104
/note="DONOR: ACCGTGAGT possible donor before repeat."
repeat_region 100122..100304
/note="10 x 15bp repeat"
misc_feature 100528
/note="DONOR: CTGGTAAGG possible donor"
misc_feature 100613
/note="BAM: Bam H1 E/e1"
repeat_region 100665..100781
/note="3x39bp repeat"
promoter complement(100860)
/note="TATA: TATAACA"
misc_feature 100919
/note="BAM: Bam H1 e1/e2"
misc_feature 101426
/note="BAM: Bam H1 e2/e3"
CDS complement(101445..102116)
/note="BZLF2 reading frame 3x NXT/S. 2.5kb late RNA
traverses BZLF2, ends unknown."
/codon_start=1
/db_xref="PID:g1334876"
/db_xref="SWISS-PROT:P03205"
/translation="MVSFKQVRVPLFTAIALVIVLLLAYFLPPRVRGGGRVAAAAITW
VPKPNVEVWPVDPPPPVNFNKTAEQEYGDKEVKLPHWTPTLHTFQVPQNYTKANCTYC
NTREYTFSYKGCCFYFTKKKHTWNGCFQACAELYPCTYFYGPTPDILPVVTRNLNAIE
SLWVGVYRVGEGNWTSLDGGTFKVYQIFGSHCTYVSKFSTVPVSHHECSFLKPCLCVS
QRSNS"
promoter 101690
/note="TATA: CATAAAA"
misc_feature 101765
/note="polyA signal: AATAAA"
promoter complement(101786)
/note="TATA: TATAAAG"
misc_feature 101947
/note="BAM: Bam H1 e3/Z"
misc_feature complement(102098)
/note="DONOR: CAGGTGAGG possible donor"
mRNA complement(102126..102341)
/note="3' terminal exon of 0.9kb and 2.8kb early RNAs"
promoter 102153
/note="TATA: TATTAAT"
misc_feature complement(102156)
/note="polyA signal: AATAAA 3' end of 0.9kb and 2.8kb RNAs
encoding BZLF1 and BRLF1"
promoter complement(102160)
/note="TATA: TATTAAT"
CDS complement(join(<102210..102338,102423..102530,
102655..103155))
/note="BZLF1 reading frame, modified from Baer et al,
1984. Has two splices within frame. 2xNXT/S. Immediate
early gene which disrupts latency (Countryman and Miller,
1985), called EB1 by Chevallier-Greco et al, 1986 and
ZEBRA by Miller."
/codon_start=1
/db_xref="PID:e276432"
/db_xref="PID:g1632794"
/translation="MMDPNSTSEDVKFTPDPYQVPFVQAFDQATRVYQDLGGPSQAPL
PCVLWPVLPEPLPQGQLTAYHVSTAPTGSWFSAPQPAPENAYQAYAAPQLFPVSDITQ
NQQTNQAGGEAPQPGDNSTVQTAAAVVFACPGANQGQQLADIGVPQPAPVAAPARRTR
KPQQPESLEECDSELEIKRYKNRVASRKCRAKFKQLLQHYREVAAAKSSENDRLRLLL
KQMCPSLDVDSIIPRTPDVLHEDLLNF"
promoter complement(102380)
/note="TATA: CATAAAT"
promoter 102415
/note="TATA:TATATAC"
promoter complement(102420)
/note="TATA: TATATAC"
mRNA complement(102426..102530)
/note="Exon of 0.9kb and 2.8kb early RNAs"
misc_feature complement(102504)
/note="polyA signal: AATAAA, apparently not functional"
repeat_region 102581..102652
/note="semi-repetitive sequence, homologous to human c-fos
3' sequence"
mRNA complement(102655..103194)
/note="First exon of 0.9kb early RNA encoding BZLF1"
misc_feature complement(102918)
/note="splice acceptor used in RZ fusion gene (Sargeant)"
promoter complement(103231)
/note="TATA: TTTAAA of BZL1 immediate early promoter gives
0.9kb RNA"
misc_feature complement(103256..103311)
/note="Upstream of BZL1, homology to 106243 to 106188"
CDS complement(103366..105183)
/note="BRLF1 reading frame, (immediate?) early gene, acts
as transcription activator."
/codon_start=1
/db_xref="PID:g1334878"
/db_xref="SWISS-PROT:P03209"
/translation="MRPKKDGLEDFLRLTPEIKKQLGSLVSDYCNVLNKEFTAGSVEI
TLRSYKICKAFINEAKAHGREWGGLMATLNICNFWAILRNNRVRRRAENAGNDACSIA
CPIVMRYVLDHLIVVTDRFFIQAPSNRVMIPATIGTAMYKLLKHSRVRAYTYSKVLGV
DRAAIMASGKQVVEHLNRMEKEGLLSSKFKAFCKWVFTYPVLEEMFQTMVSSKTGHLT
DDVKDVRALIKTLPRASYSSHAGQRSYVSGVLPACLLSTKSKAVETPILVSGADRMDE
ELMGNDGGASHTEARYSESGQFHAFTDELESLPSPTMPLKPGAQSADCGDSSSSSSDS
GNSDTEQSEREEARAEAPRLRAPKSRRTSRPNRGQTPCPSNAAEPEQPWIAAVHQESD
ERPIFPHPSKPTFLPPVKRKKGLRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRP
FHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDP
DEETSQAVKALREMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNL
DSPLTPELNEILDTFLNDECLLHAMHISTGLSIFDTSLF"
misc_feature complement(103453..103462)
/note="TAATGAAATC sequence"
misc_feature 103741
/note="BAM: Bam H1 Z/g"
misc_feature 103816
/note="BAM: Bam H1 g/R"
mRNA complement(104926..105185)
/note="exon in RZ fusion gene (Sargeant)"
mRNA complement(104927..104989)
/note="BRLF2 poss. small 5' exon"
promoter 105016
/note="TATA: TATAAAT before BRRF1, possible promoter for
1.1 kb early RNA encoding BRRF1"
promoter complement(105019)
/note="TATA: TATAAAT before BRLF2"
CDS 105182..106114
/note="BRRF1 early reading frame"
/codon_start=1
/db_xref="PID:g1334877"
/db_xref="SWISS-PROT:P03207"
/translation="MASSNRGNARPLKSFLHELYLKHYPEVGDVVHLLNTIGVDCDLP
PSHPLLTAQRGLFLARVLQAVQQHKLLEDTIVPKILKKLAYFLELLSYYSPKDEQRDI
AEVLDHLKTNRDLGLDDRLWALIRKLRQDRHHASVNVLMPGSDYTAVSLQYYDGISIG
MRKVIADVCRSGYASMPSMTATHNLSHQLLMASGPSEEPCAWRGFFNQVLLWTVALCK
FRRCIYYNYIQGSIATISQLLHLEIKALCSWIISQDGMRLFQHSRPLLTLWESVAANQ
EVTDAITLPDCAEYIDLLKHTKHVLENCSAMQYK"
misc_feature complement(105185)
/note="ACCEPT: splice acceptor in 2.8kb early RNA encoding
BRLF1 and RZ fusion gene (Sargeant)"
promoter 105213
/note="TATA: CATTAAA"
misc_feature 106110
/note="polyA signal: AATAAA, 3' end of early 1.1kb RNA
encoding BRRF1"
misc_feature complement(106125)
/note="DONOR: CAGGTAAGA possible donor"
misc_feature complement(106188..106243)
/note="Homology to upstream region of BZL1"
promoter complement(106213)
/note="TATA: CATAAAA"
promoter 106243
/note="TATA: TATAAAA before BRRF2, possible promoter for
1.8 kb RNA encoding BRRF2"
CDS 106302..107915
/note="BRRF2 reading frame"
/codon_start=1
/db_xref="PID:g1334879"
/db_xref="SWISS-PROT:P03210"
/translation="MSGQQRGSVILVPEHLAGALTKLMSDFITGQDVTLSGGNIAVKI
RDAINQTPGGGDVAILSSLFALWNALPTSGRQSSRDDLIPAAVQALTTAHNLCLGVIP
GETSHKDTPESLLRAIVTGLQKLWVDSCGCPECLQCLKGLKAIKPGLYEIPRIIPHTK
QCSPVNLLNMLVHKLVALRGHVQLAYDARVLTPDFHEIPDLDDSDAVFARTLLAALFH
LNMFFILKDYITQDSMSLKQALSGHWMSATGNPLPAAPETLRDYLEAFRNSDNHFYLP
TTGPLNTFQFPEELLGRVVVIDSSLCAASHVQDVITHGVGAGVPRPRFSALPPAPSRE
PQQTCSQLTSRGNESSRRNLGQPGGTSPAVPPVCPIVSLTASGAKQNRGGMGSLHLAK
PEETSPAVSPVCPIASPAASRSKQHCGVTGSSQAAPSFSSVAPVASLSGDLEEEEEGS
RESPSLPSSKKGDEEFEAWLEAQDANLEDVQREFSGLRVIGDEDEDGSEDGEFSDLDL
SDSDHEGDEGGGAVGGGRSLHSLYSLSVV"
promoter complement(106385)
/note="TATA: GATAAAA"
misc_feature complement(106973)
/note="polyA signal: AATAAA"
promoter complement(107124)
/note="TATA: GATAAAA"
misc_feature 107457
/note="BAM: Bam H1 R/f"
misc_feature 107565
/note="BAM: Bam H1 f/K"
misc_feature 107914
/note="polyA signal: AATAAA, 3' end of 1.8kb RNA encoding
BBRF2"
misc_feature 107942
/note="ACCEPT: splice acceptor for EBNA-1 RNA (from
98730)"
CDS 107950..109875
/note="BKRF1 encodes EBNA-1 protein, latent cycle gene."
/codon_start=1
/db_xref="PID:g1334880"
/db_xref="SWISS-PROT:P03211"
/translation="MSDEGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRG
RGRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGG
AGAGGGAGAGGGAGGAGGAGGAGAGGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAG
GGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGAGGAGGAGAGGA
GAGGGAGGAGGAGAGGAGAGGAGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAG
GAGAGGGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGAGGAGAGGGGRGRGGS
GGRGRGGSGGRGRGGSGGRRGRGRERARGGSRERARGRGRGRGEKRPRSPSSQSSSSG
SPPRRPPPGRRPFFHPVGEADYFEYHQEGGPDGEPDVPPGAIEQGPADDPGEGPSTGP
RGQGDGGRRKKGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVF
VYGGSKTSLYNLRRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFL
QTHIFAEVLKDAIKDLVMTKPAPTCNIRVTVCSFDDGVDLPPWFPPMVEGAAAEGDDG
DDGDEGGDGDEGEEGQE"
repeat_region 108217..108924
/note="EBNA triplet repeat GGA,GCA,GGG."
misc_feature 109856
/note="DONOR: AGGGTGAGG possible donor at end BKRF1"
promoter 109905
/note="TATA: TATTAAA before BKRF2, possible start for
2.3kb late RNA"
misc_feature 109906
/note="polyA signal: ATTAAA"
misc_feature 109937
/note="polyA signal: AATAAA 3' end of EBNA-1 RNA"
CDS 109958..110371
/note="BKRF2 reading frame"
/codon_start=1
/db_xref="PID:g1334881"
/db_xref="SWISS-PROT:P03212"
/translation="MRAVGVFLAICLVTIFVLPTWGNWAYPCCHVTQLRAQHLLALEN
ISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTG
HLRELLTTLETLYGSFSVEDLFGANLNRYAWHRGG"
misc_feature 110271
/note="DONOR: TCCGTGAGT possible donor at end of BKRF2"
CDS 110353..111120
/note="BKRF3 reading frame, homologous to RF 59 VZV"
/codon_start=1
/db_xref="PID:e25020"
/db_xref="PID:g1632795"
/db_xref="SWISS-PROT:P12888"
/translation="MASRGLDLWLDEHVWKRKQEIGVKGENLLLPDLWLDFLQLSPIF
QRKLAAVIACVRRLRTQATVYPEEDMCMAWARFCDPSDIKVVILGQDPYHGGQANGLA
FSVAYGFPVPPSLRNIYAELHRSLPEFSPPDHGCLDAWASQGVLLLNTILTVQKGKPG
SHADIGWAWFTDHVISLLSERLKACVFMLWGAKAGDKASLINSKKHLVLTSQHPSPLA
QNSTRKSAQQKFLGNNHFVLANNFLREKGLGEIDWRL"
misc_feature 111098
/note="DONOR: TCGGTGAGA possible donor at end BKRF3"
CDS 111134..111787
/note="BKRF4 reading frame, contains complex repetitive
sequence"
/codon_start=1
/db_xref="PID:e25021"
/db_xref="PID:g1632796"
/db_xref="SWISS-PROT:P30117"
/translation="MAMFLKSRGVRSCRDRRLLSDEEEETSQSSSYTLGSQASQSIQE
EDVSDTDESDYSDEDEEIDLEEEYPSDEDPSEGSDSDPSWHPSDSDESDYSESDEDEA
TPGSQASRSSRVSPSTQQSSGLTPTPSFSRPRTRAPPRPPAPAPVRGRASAPPRPPAP
VQQSTKDKGPHRPTRPVLRGPAPRRPPPPSSPNTYNKHMMETTPPIKGNNNYNWPWL"
misc_feature 111272
/note="DONOR: GACGTGAGT poss.donor before rpt.seq. in
BKRF4"
misc_feature 111719
/note="polyA signal: AATAAA"
misc_feature 111787
/note="polyA signal: AATAAA : currently unknown which is
3' end of the 2.3kb late and 1.1kb early RNAs"
CDS complement(111830..114259)
/note="BBLF4 early reading frame, very good homology to
RF55 VZV"
/codon_start=1
/db_xref="PID:g1334885"
/db_xref="SWISS-PROT:P03214"
/translation="MAEEPRAPEALSSTFMLNMTSDASVRRIVRRIGTLARRRVQQLP
DMETFSPEFDPELSEPPFLPFSAYVITGTAGAGKSTSVSCLHHTMDCLVTGATTVAAQ
NLSQTLRAYCPTVYSAFGFKSRHINMTQRVSSHGRSTDAALEELQRRDLAKYWPVLSD
IAAEFRRTKPRGLYSGVSGPAFEVLRDMHQGQLWTTNVIVVDEAGTLSVHILTAVVFC
YWFFNAWLRTPLYRRGRIPCIVCVGSPTQTDAFQSSFSHETQVNKIRECDNILTFLVG
NPRAATYVDVARNWALFINNKRCTDVQFGHLMKTLEYGLELSPDILAYVDRFVVPRAA
IMDPAQYVGWTRLFLSHAEVKTFLTTLHATLKTAGQGRAARGTGGDGGGVTMFTCPVE
CEVFLDPLAQYKTLVGLPGLTAHTWLQKNYARLGNYSQFADQDMVPVGTEQDEERVKV
TYNVTYVKHSSVSVNCKTKKSICGYTGTFGDFMDTLEADSFVEAHGHEQPEYVYSFLA
RLIYGGIYAFSHGGHSLCENGEYVAELGAVPLPGRTWDPEVTAGMELGELPLEVAWDG
ERSPAAVFYARVLAPPAANSAPLCSLLNIYNDLRAYFRQCLDVAVRYGGREFRDLPFC
TFTNNMLIRDNIEFTSDEPLLHGLLDYASTTENYTLLGYTHLNVFFGIRGKQQPQDAG
SSRMPRLMVKDEAGFVCCLEHNTNKLYETIEDKSLNLCSIRDYGISSKLAMTIAKAQG
LSLNKVAICFGSHRNIKPGHVYVALSRARHSNCVVMDRNPLSEMITGEGNPASGYIVD
ALKNSRALLVY"
misc_feature complement(111830)
/note="polyA signal: AATAAA"
promoter 112471
/note="TATA: TATATAT"
promoter complement(112476)
/note="TATA: TATATAA"
misc_feature 112620
/note="BAM: Bam H1 K/B"
promoter 113876
/note="TATA: TATTTAT before BBRF1"
promoter complement(113885)
/note="TATA: CATAAAT"
CDS 114204..116045
/note="BBRF1 late reading frame, homologous to RF 54 VZV"
/codon_start=1
/db_xref="PID:g1334884"
/db_xref="SWISS-PROT:P03213"
/translation="MFNMNVDESASGALGSSAIPVHPTPASVRLFEILQGKYAYVQGQ
TIYANLRNPGVFSRQVFTHLFKRAISHCTYDDVLHDWNKFEACIQKRWPSDDSCASRF
RESTFESWSTTMKLTVRDLLTTNIYRVLHSRSVLSYERYVDWICATGMVPAVKKPITQ
ELHSKIKSLRDRCVCRELGHERTIRSIGTELYEATKEIIESLNSTFIPQFTEVTIEYL
PRSDEYVAYYCGRRIRLHVLFPPAIFAGTVTFDSPVQRLYQNIFMCYRTLEHAKICQL
LNTAPLKAIVGHGGRDMYKDILAHLEQNSQRKDPKKELLNLLVKLSENKTISGVTDVV
EEFITDASNNLVDRNRLFGQPGETAAQGLKKKVSNTVVKCLTDQINEQFDQINGLEKE
RELYLKKIRSMESQLQASLGPGGNNPAASAPAAVAAEAASVDILTGSTASAIEKLFNS
PSASLGARVSGHNESILNSFVSQYIPPSREMTKDLTELWESELFNTFKLTPVVDNQGQ
RLYVRYSSDTISILLGPFTYLVAELSPVELVTDVYATLGIVEIIDELYRSSRLAIYIE
DLGRKYCPASATGGDHGIRQAPSARGDTEPDHAKSKPARDPPPGAGS"
CDS 115948..116784
/note="BBRF2 late reading frame, homologous to RF 53 VZV"
/codon_start=1
/db_xref="PID:e25024"
/db_xref="PID:g1632797"
/db_xref="SWISS-PROT:P29882"
/translation="MASGKHHQPGGTRSLTMQKVSLRVTPRLVLEVNRHNAICVATNV
PEFYNARGDLNIRDLRAHVKARMISSQFCGYVLVSLLDSEDQVDHLNIFPHVFSERMI
LYKPNNVNLMEMCALLSMIENAKSPSIGLCREVLGRLTLLHSKCNNLDSLFLYNGART
LLSTLVKYHDLEEGAATPGPWNEGLSLFKLHKELKRAPSEARDLMQSLFLTSGKMGCL
ARSPKDYCADLNKEEDANSGFTFNLFYQDSLLTKHFQCQTVLQTLRRKCLGSDTVSKI
IP"
promoter complement(116683)
/note="TATA: GATAAAA"
misc_feature complement(116696)
/note="polyA signal: AATAAA"
CDS complement(116784..117386)
/note="BBLF3 early reading frame, spliced to BBLF2. BBLF3
contains a consensus nucleotide binding site; Author-given
protein sequence is in conflict with the conceptual
translation"
/codon_start=1
/db_xref="PID:e25025"
/db_xref="PID:g1334887"
/translation="AFLQGVKDSEDASRLDRDVMGGEATVARRHIRVKARRGPGCLLM
AIFQGDLYVGGCREHSGPFLVWHEAFSWTLDQLAARPEADKAPPSHDHLLTLVRDLTR
RLAPGRRRNRFWALPRAWLQRLRRAGLRLSGSHVCLLDKDGARPAPCQTATEHGLSPT
AYFREIMAFLLDVISALHPGYTIPMEITRETDLLMTVLSLF"
misc_feature 116785
/note="polyA signal: AATAAA"
intron complement(117386..117515)
/note="intron spliced out in RNA linking BBLF2 and BBLF3"
CDS complement(117515..119080)
/note="BBLF2 early reading frame, spliced to BBLF3;
Author-given protein sequence is in conflict with the
conceptual translation"
/codon_start=1
/db_xref="PID:e25026"
/db_xref="PID:g1334888"
/db_xref="SWISS-PROT:P30118"
/translation="PDVLKGPVLLRSQTMMETPAESVRARVSSVTFYNVTQTAGRWWA
IWVVGIVPIKREDVETLIVVQACQPPLGGSLEPPVVNAPSTTELNFLRWERELRRSGG
LIAMLADAAEKDLFDLSFRTRDRRLLSAARVEDEQGLIFQPLFPAQVVCQSCSGDDGR
DQQPPPVDGFGSEMEGEQTCPHAQRHSESPGQLDVYIRTPRGDVFTYSTETPDDPSPV
PFRDILRPVTYEVDLVSSDGATGRGGDARRHRVSLKILEPAGGFESWLVNSWSMAGGG
LYAFLRSIYASCYANHRGTKPIFYLLDPELCPGGSDFQPYVPGFPFLPIHYVGRARPA
FWHRAPHSEGLLLLDLNLGVSGTPLADALLGLDARSGQRRGSLLLQQIWPPTRKEINP
RHVCTREGGEGGGEDETTVVGRAEATAILEADATWWLYELARCHLSARGAPVGTPDGG
GQARDAQTWLRALHRYGTSDTRRALGGLYTAVTRVLLHAAADLGLTWAYADEFILGFV
APTSAHPSEEPLAQ"
promoter 118981
/note="TATA: TATAAAA BBR1 late promoter before BBRF3"
promoter 119067
/note="TATA: TTTAAAA BBR2 late promoter ?"
promoter 119098
/note="TATA: TATTTAA BBR3 late promoter before BBRF3"
misc_feature 119108
/note="DONOR: AAGGTGAAT possible donor"
CDS 119137..120354
/note="BBRF3 late reading frame"
/codon_start=1
/db_xref="PID:g1334889"
/db_xref="SWISS-PROT:P03215"
/translation="MKSSKNDTFVYRTWVKTLVVYFVMFVMSAVVPITAMFPNLGYPC
YFNALVDYGALNLTNYNLAHHLTPTLYLEPPEMFVYITLVFIADCVAFIYYACGEVAL
IKARKKVSGLTDLSAWVSAVGSPTVLFLAILKLWSIQVFIQVLSYKHVFLSAFVYFLH
FLASVLHACACVTRFSPVWVVKAQDNSIPQDTFLWWVVFYLKPVVTNLYLGCLALETL
VFSLSVFLALGNSFYFMVGDMVLGAVNLFLILPIFWYILTEVWLASFLRHNFGFYCGM
FIASIILILPLVRYEAVFVSAKLHTTVAINVAIIPILCSVAMLIRICRIFKSMRQGTD
YVPVSETVELELESEPRPRPSRTPSPGRNRRRSSTSSSSSRSTRRQRPVSTQALVSSV
LPMTTDSEEEIFP"
misc_feature 120260
/note="ACCEPT: ATCTTCCTCCAGGT possible acceptor"
misc_feature 120358
/note="polyA signal: AATAAA"
CDS complement(120747..120974)
/note="BBLF1 late reading frame, possibly homologous to RF
49 VZV"
/codon_start=1
/db_xref="PID:g1334890"
/db_xref="SWISS-PROT:P03216"
/translation="MGALWSLCRRRVNSIGDVDGGIINLYNDYEEFNLETTKLIAAEE
GRACGETNEGLEYDEDSENDELLFLPNKKPN"
misc_feature complement(120764)
/note="polyA signal: AATAAA, 3' end of 0.6kb late, 1.6kb
early, 3.0kb early RNAs"
CDS complement(120929..122341)
/note="BGLF5 early reading frame, homologous to RF 48 VZV
and alkaline exonuclease of HSV"
/codon_start=1
/db_xref="PID:g1334891"
/db_xref="SWISS-PROT:P03217"
/translation="MADVDELEDPMEEMTSYTFARFLRSPETEAFVRNLDRPPQMPAM
RFVYLYCLCKQIQEFSGETGFCDFVSSLVQENDSKDGPSLKSIYWGLQEATDEQRTVL
CSYVESMTRGQSENLMWDILRNGIISSSKLLSTIKNGPTKVFEPAPISTNHYFGGPVA
FGLRCEDTVKDIVCKLICGDASANRQFGFMISPTDGIFGVSLDLCVNVESQGDFILFT
DRSCIYEIKCRFKYLFSKSEFDPIYPSYTALYKRPCKRSFIRFINSIARPTVEYVPDG
RLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDLVADSLAANRGVESMLYVMTDPSENAG
RIGIKDRVPVNIFINPRHNYFYQVLLQYKIVGDYVRHSGGGKPGRDCSPRVNIVTAFF
RKRSPLDPATCTLGSDLLLDASVEIPVAVLVTPVVLPDSVIRKTLSTAAGSWKAYADN
TFDTAPWVPSGLFADDESTP"
promoter complement(121331)
/note="TATA: TATTAAA BBL1 late promoter before BBLF1"
promoter 121669
/note="TATA: CATAAAT"
promoter 121697
/note="TATA: TATAAAG"
promoter 121772
/note="TATA: CATAAAG"
misc_feature 122313
/note="BAM: Bam H1 B/G"
CDS complement(122328..123692)
/note="BGLF4 early reading frame, homologous to RF 47 VZV;
Author-given protein sequence is in conflict with the
conceptual translation"
/codon_start=1
/db_xref="PID:e25030"
/db_xref="PID:g1334892"
/db_xref="SWISS-PROT:P13288"
/translation="SGWRSSVSRSLRPETSCDRPSSHLRNMDVNMAAELSPTNSSSSG
ELSVSPEPPRETQAFLGKVTVIDYFTFQHKHLKVTNIDDMTETLYVKLPENMTRCDHL
PITCEYLLGRGSYGAVYAHADNATVKLYDSVTELYHELMVCDMIQIGKATAEDGQDKA
LVDYLSACTSCHALFMPQFRCSLQDYGHWHDGSIEPLVRGFQGLKDAVYFLNRHCGLF
HSDISPSNILVDFTDTMWGMGRLVLTDYGTASLHDRNKMLDVRLKSSKGRQLYRLYCQ
REPFSIAKDTYKPLCLLSKCYILRGAGHIPDPSACGPVGAQTALRLDLQSLGYSLLYG
IMHLADSTHKIPYPNPDMGFDRSDPLYFLQFAAPKVVLLEVLSQMWNLNLDMGLTSCG
ESPCVDVTAEHMSQFLQWCRSLKKRFKESYFFNCRPRFEHPHLPGLVAELLADDFFGP
DGRRG"
misc_feature complement(123506)
/note="DONOR: AAGGTGACT possible donor"
CDS complement(123941..124939)
/note="BGLF3 reading frame"
/codon_start=1
/db_xref="PID:g1334894"
/db_xref="SWISS-PROT:P03220"
/translation="MFNAVKADMPDDPMLARRYGQCLELALEACQDTPEQFKLVETPL
KSFLLVSNILPQDNRPWHEARSSGRVAEDDYDFSSLALELLPLNPRLPEEWQFGGQGW
SSRMEPSQPEMGMGLCFEVFDGDLMRIALAWNKDEVIGQALQILAHSQTWTSLVPEDP
LPWMWALFYGPRSHCEERHCVYAAARGKRGPILLPTAVYTPCANIEAFLAHLTRCVYA
LYLDVRDWKGEDIAPPFDVSRLNKMAKQLCLLPQEPFCITRVCLLCLLHKQNLNAQYK
RPVDTYDPCLILTGEAERYMVDAVGNYREASTGTTVLYPTYDLGSIVADMVTYEDE"
promoter complement(124117)
/note="TATA: TATAAAA"
misc_feature complement(124219)
/note="polyA signal: AATAAA"
CDS 124938..125915
/note="BGRF1 reading frame, homologous to RF 45 VZV and
spliced HSV gene (Costa et al, 1985). Spliced to BDRF1.
Northern blots in BGRF1 detect 2.7, 2.6, 2.1kb late and
1.9kb early RNAs. 2.6, 2.1kb RNAs very weak."
/codon_start=1
/db_xref="PID:g1334893"
/db_xref="SWISS-PROT:P03219"
/translation="MLYASQRGRLTENLRNALQQDSTTQGCLGAETPSIMYTGAKSDR
WAHPLVGTIHASNLYCPMLRAYCRHYGPRPVFVASDESLPMFGASPALHTPVQVQMCL
LPELRDTLQRLLPPPNLEDSEALTEFKTSVSSARAILEDPNFLEMREFVTSLASFLSG
QYKHKPARLEAFQKQVVLHSFYFLISIKSLEITDTMFDIFQSAFGLEEMTLEKLHIFK
QKASVFLIPRRHGKTWIVVAIISLILSNLSNVQIGYVAHQKHVASAVFTEIIDTLTKS
FDSKRVEVNKETSTITFRHSGKISSTVMCATCFNKNVRPDVSVLGNCRA"
CDS join(124938..125873,129215..130351)
/note="BDRF1 reading frame"
/codon_start=1
/product="probable DNA packaging protein"
/db_xref="PID:e276433"
/db_xref="PID:g1632798"
/translation="MLYASQRGRLTENLRNALQQDSTTQGCLGAETPSIMYTGAKSDR
WAHPLVGTIHASNLYCPMLRAYCRHYGPRPVFVASDESLPMFGASPALHTPVQVQMCL
LPELRDTLQRLLPPPNLEDSEALTEFKTSVSSARAILEDPNFLEMREFVTSLASFLSG
QYKHKPARLEAFQKQVVLHSFYFLISIKSLEITDTMFDIFQSAFGLEEMTLEKLHIFK
QKASVFLIPRRHGKTWIVVAIISLILSNLSNVQIGYVAHQKHVASAVFTEIIDTLTKS
FDSKRVEVNKETSTITFRHSGKISSTVMCATCFNKNSIRGQTFHLLFVDEANFIKKEA
LPAILGFMLQKDAKIIFISSVNSADQATSFLYKLKDAQERLLNVVSYVCQEHRQDFDM
QDSMVSCPCFRLHIPSYITMDSNIRATTNLFLDGAFSTELMGDTSSLSQGSLSRTVRD
DAINQLELCRVDTLNPRVAGRLASSLYVYVDPAYTNNTSASGTGIAAVTHDRADPNRV
IVLGLEHFFLKDLTGDAALQIATCVVALVSSIVTLHPHLEEVKVAVEGNSSQDSAVAI
ASIIGESCPLPCAFVHTKDKTSSLQWPMYLLTNEKSKAFERLIYAVNTASLSASQVTV
SNTIQLSFDPVLYLISQIRAIKPIPLRDGTYTYTGKQRNLSDDVLVALVMAHFLATTQ
KHTFKKVH"
promoter complement(125113)
/note="TATA: TATAAAT before BGLF3"
misc_feature complement(125484)
/note="polyA signal: AATAAA, 3' end of 1.6kb late, 1.8kb
late, 3.0kb late and 3.7kb early RNAs"
CDS complement(125863..126873)
/note="BGLF2 late reading frame, poor homology to RF 44
VZV"
/codon_start=1
/db_xref="PID:g1334895"
/db_xref="SWISS-PROT:P03221"
/translation="MASAANSSREQLRKFLNKECLWVLSDASTPQMKVYTATTAVSAV
YVPQIAGPPKTYMNVTLIVLKPKKKPTYVTVYINGTLATVARPEVLFTKAVQGPHSLT
LMYFGVFSDAVGEAVPVEIRGNPVVTCTDLTTAHVFTTSTAVKTVEELQDITPSEIIP
LGRGGAWYAEGALYMFFVNMDMLMCCPNMPTFPSLTHFINLLTRCDNGECVTCYGAGA
HVNILRGWTEDDSPGTSGTCPCLLPCTALNNDYVPITGHRALLGLMFKPEDAPFVVGL
RFNPPKMHPDMSRVLQGVLANGKEVPCTAQPWTLLRFSDLYSRAMLYNCQVLKRQVLH
SY"
promoter 126277
/note="TATA: GATAAAA"
CDS complement(126851..128374)
/note="BGLF1 late reading frame"
/codon_start=1
/db_xref="PID:g1334896"
/db_xref="SWISS-PROT:P03222"
/translation="MDVHIDNQVLSGLGTPLLVHLFVPDTVMAELCPNRVPNCEGAWC
QTLFSDRTGLTRVCRVFAARGMLPGRPSHRGTFTSVPVYCDEGLPELYNPFHVAALRF
YDEGGLVGELQIYYLSLFEGAKRALTDGHLIREASGVQESAAAMQPIPIDPGPPGGAG
IEHMPVAAAQVEHPKTYDLKQILLEITQEENRGEQRLGHAGSPALCLGLRLRAGAETK
AAAETSVSKHHPALENPSNIRGSAGGEGGGGRAGTGGTVGVGSGALSRVPVSFSKTRR
AIRESRALVRGIAHIFSPHALYVVTYPELSAQGRLHRMTAVTHASPATDLAEVSILGA
PEREFRFLISVALRISASFREKLAMQAWTAQQEIPVVIPTSYSRIYKNSDLIREAFFT
VQTRVSWESCWVKATISNAPKTPDACLWIDSHPLYEEGASAWGKVIDSRPPGGLVGAA
SQLVALGTDGHCVHLATTSDGQAFLVLPGGFVIKGQLALTPEERGYILARHGIRREQ"
promoter complement(126929)
/note="TATA: TATTAAA EEL8 late promoter before BGLF2,
gives 1.6kb late RNA"
promoter complement(127237)
/note="TATA: TATAAAA, potential promoter for 1.8kb late
RNA"
misc_feature 128029
/note="polyA signal: AATAAA"
CDS complement(128344..129021)
/note="BDLF4 early reading frame"
/codon_start=1
/db_xref="PID:g1334897"
/db_xref="SWISS-PROT:P03223"
/translation="MSDQGRLSLPRGEGGTDEPNPRHLCSYSKLEFHLPLPESMASVF
ACWGCGEYHVCDGSSECTLIETHEGVVCALTGNYMGPHFQPALRPWTEIRQDTQDQRD
KWEPEQVQGLVKTVVNHLYHYFLNENVISGVSEALFDQEGALRPHIPALVSFVFPCCL
MLFRGASSEKVVDVVLSLYIHVIISIYSQKTVYGALLFKSTRNKRYDAVAKRMRELWM
STLTTKC"
promoter complement(128432)
/note="TATA: TATTTAA before BGLF1, potential promoter for
3.0kb late RNA"
misc_feature 128848
/note="BAM: Bam H1 G/D"
promoter complement(129054)
/note="TATA: TATTTGC before BDLF4, potential promoter for
3.7kb early RNA"
mat_peptide 129188..130348
/note="BDRF1 reading frame, homologous to RF 42 VZV and
spliced gene in HSV (Costa et al, 1985). Spliced from
BGRF1. Northern blots in BDRF1 detect 2.7, 2.6 kb late and
1.9kb early RNAs. Possibly also 1.8kb early RNA."
promoter 129374
/note="TATA: TATAAGC"
promoter complement(129377)
/note="TATA: TATAAAG"
misc_feature 129413
/note="DONOR: GTGGTAAGT possible donor"
misc_feature 130347
/note="polyA signal: ATTAAA"
misc_feature complement(130359)
/note="polyA signal: AATAAA, 3' end of 0.9kb late RNA,
2.3kb late RNA and 3.2kb late RNA"
CDS complement(130362..131066)
/note="BDLF3 late reading frame 9xNXT/S"
/codon_start=1
/db_xref="PID:g1334899"
/db_xref="SWISS-PROT:P03224"
/translation="MAHARDKAGAVMAMILICETSLIWTSSGSSTASAGNVTGTTAVT
TPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTFTGTTVTPVPTTSNASTINV
TTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNA
TKTTAELPTVPDERQPSLSYGLPLWTLVFVGLTFLMLILIFAAGLMMSAKNKPLDEAL
LTNAVTRDPSLYKGLV"
promoter complement(131104)
/note="TATA: TATAAAA EEL4 late promoter before BDLF3,
gives 0.9kb late RNA"
CDS complement(131127..132389)
/note="BDLF2 late reading frame"
/codon_start=1
/db_xref="PID:g1334900"
/db_xref="SWISS-PROT:P03225"
/translation="MVDEQVAVEHGTVSHTISREEDGVVHERRVLASGERVEVFYKAP
APRPREGRASTFHDFTVPAAAAVPGPEPEPEPHPPMPIHANGGGETKTNTQDQNQNQT
TRTRTNAKAEERTAEMDDTMASSGGQRGAPISADLLSLSSLTGRMAAMAPSWMKSEVC
GERMRFKEDVYDGEAETLAEPPRCFMLSFVFIYYCCYLAFLALLAFGFNPLFLPSFMP
VGAKVLRGKGRDFGVPLSYGCPTNPFCKVYTLIPAVVINNVTYYPNNTDSHGGHGGFE
AAALHVAALFESGCPNLQAVTNRNRTFNVTRASGRVERRLVQDMQRVLASAVVVMHHH
CHYETYYVFDGVGPEFGTIPTPCFKDVLAFRPSLVTNCTAPLKTSVKGPNWSGAAGGM
KRKQCRVDRLTDRSFPAYLEEVMYVMVQ"
promoter 132266
/note="TATA: TATAAAA"
CDS complement(132400..133305)
/note="BDLF1 late reading frame, poor homology to RF 41
VZV"
/codon_start=1
/db_xref="PID:g1334901"
/db_xref="SWISS-PROT:P25214"
/translation="MDLKVVVSLSSRLYTDEIAKMQQRIGCILPLASTHGTQNVQGLG
LGQVYSLETVPDYVSMYNYLSDCTLAVLDEVSVDSLILTKIVPGQTYAIKNKYQPFFQ
WHGTGSLSVMPPVFGREHATVKLESNDVDIVFPMVLPTPIAEEVLQKILLFNVYSRVV
MQAPGNADMLDVHMHLGSVSYLGHHYELALPEVPGPLGLALLDNLSLYFCIMVTLLPR
ASMRLVRGLIRHEHHDLLNLFQEMVPDEIARIDLDDLSVADDLSRMRVMMTYLQSLAS
LFNLGPRLATAAYSQETLTATCWLR"
promoter complement(132476)
/note="TATA: TATTTAA before BDLF2, likely promoter for
2.3kb late RNA"
misc_feature complement(133312)
/note="polyA signal: AATAAA, 3' end of 4.5kb late RNA"
CDS complement(133321..137466)
/note="BcLF1 late reading frame, homologous to RF 40 VZV
and major capsid protein of HSV"
/codon_start=1
/db_xref="PID:g1334902"
/db_xref="SWISS-PROT:P03226"
/translation="MASNEGVENRPFPYLTVDADLLSNLRQSAAEGLFHSFDLLVGKD
AREAGIKFEVLLGVYTNAIQYVRFLETALAVSCVNTEFKDLSRMTDGKIQFRISVPTI
AHGDGRRPSKQRTFIVVKNCHKHHISTEMELSMLDLEILHSIPETPVEYAEYVGAVKT
VASALQFGVDALERGLINTVLSVKLRHAPPMFILQTLADPTFTERGFSKTVKSDLIAM
FKRHLLEHSFFLDRAENMGSGFSQYVRSRLSEMVAAVSGESVLKGVSTYTTAKGGEPV
GGVFIVTDNVLRQLLTFLGEEADNQIMGPSSYASFVVRGENLVTAVSYGRVMRTFEHF
MARIVDSPEKAGSTKSDLPAVAAGVEDQPRVPISAAVIKLGNHAVAVESLQKMYNDTQ
SPYPLNRRMQYSYYFPVGLFMPNPKYTTSAAIKMLDNPTQQLPVEAWIVNKNNLLLAF
NLQNALKVLCHPRLHTPAHTLNSLNAAPAPRDRRETYSLQHRRPNHMNVLVIVDEFYD
NKYAAPVTDIALKCGLPTEDFLHPSNYDLLRLELHPLYDIYIGRDAGERARHRAVHRL
MVGNLPTPLAPAAFQEARGQQFETATSLAHVVDQAVIETVQDTAYDTAYPAFFYVVEA
MIHGFEEKFVMNVPLVSLCINTYWERSGRLAFVNSFSMIKFICRHLGNNAISKEAYSM
YRKIYGELIALEQALMRLAGSDVVGDESVGQYVCALLDPNLLPPVAYTDIFTHLLTVS
DRAPQIIIGNEVYADTLAAPQFIERVGNMDEMAAQFVALYGYRVNGDHDHDFRLHLGP
YVDEGHADVLEKIFYYVFLPTCTNAHMCGLGVDFQHVAQTLAYNGPAFSHHFTRDEDI
LDNLENGTLRDLLEISDLRPTVGMIRDLSASFMTCPTFTRAVRVSVDNDVTQQLAPNP
ADKRTEQTVLVNGLVAFAFSERTRAVTQCLFHAIPFHMFYGDPRVAATMHQDVATFVM
RNPQQRAVEAFNRPEQLFAEYREWHRSPMGKYAAECLPSLVSISGMTAMHIKMSPMAY
IAQAKLKIHPGVAMTVVRTDEILSENILFSSRASTSMFIGTPNVSRREARVDAVTFEV
HHEMASIDTGLSYSSTMTPARVAAITTDMGIHTQDFFSVFPAEAFGNQQVNDYIKAKV
GAQRNGTLLRDPRTYLAGMTNVNGAPGLCHGQQATCEIIVTPVTADVAYFQKSNSPRG
RAACVVSCENYNQEVAEGLIYDHSRPDAAYEYRSTVNPWASQLGSLGDIMYNSSYRQT
AVPGLYSPCRAFFNKEELLRNNRGLYNMVNEYSQRLGGHPATSNTEVQFVVIAGTDVF
LEQPCSFLQEAFPALSASSRALIDEFMSVKQTHAPIHYGHYIIEEVAPVRRILKFGNK
VVF"
misc_feature complement(133332)
/note="DONOR: AAGGTGGTT possible donor"
promoter complement(133352)
/note="TATA: TATTAAA before BDLF1"
promoter complement(133386)
/note="TATA: TATATAA"
misc_feature 135178
/note="polyA signal: AATAAA"
promoter 135394
/note="TATA: TATAAGT"
misc_feature 136624
/note="polyA signal: AATAAA"
misc_feature 136868
/note="BAM: Bam H1 D/c"
promoter complement(137710)
/note="TATA: TATTAAA EHL1 promoter before BcLF1, gives
4.5kb late RNA"
promoter 137857
/note="TATA: CATAAAC"
CDS 137991..139718
/note="BcRF1 reading frame"
/codon_start=1
/db_xref="PID:e25010"
/db_xref="PID:g1632799"
/db_xref="SWISS-PROT:P25215"
/translation="MLAHLNQVTRIPPCPPFSGREARLKFHFFSWSTFMLSWPNNATL
REIRTRAATNLTHHPHLVDTLYHASPQTPFLTRSGALYRFVTCCNCTLPNISIQQCKA
GDRPGDLEIILQSNGGGRPASFQFPSSPTGSLLRCIVAASLLPEVSVGHQELSPLRSR
SQGGQTDVRSGPDPARRLVALLRREDGAPKDPPLGPFGHPRGPGPAKSEDEESERRDA
PPPPLDSSFQASRLVPVGPGFRLLVFNTNRVINTKLVCSEPLVKMRVCNVPRLINNFV
ARKYVVKETAFTVSLFFTDGVGANLAINVNISGTYLSFLLAMTSLRCFLPVEAIYPAA
VSNWNSTLDLHGLENQSLVRENRSGVFWTTNFPSVVSCRDGLNVSWFKAATATISRVH
GQTLEQHLIREITPIVTHREAKISRIKNRLFTLLELRNRSQIQVLHKRFLEGLLDCAS
LLRLDPSCINRIASEGLFDFSKRSIAHSKNRHECALLGHRHSANVTKLVVNERKTRLD
ILGRNANFLTRCKHQVNLRQSPIFLTLLRHIRRRLGLGRASVKREITLLLAHLRKKTA
PIHCRDAQV"
misc_feature 138019
/note="BAM: Bam H1 c/b"
misc_feature 139352
/note="BAM: Bam H1 b/T"
CDS 139642..140916
/note="BTRF1 reading frame. Northern blots detect 0.95
late and 3.8kb early RNA; Author-given protein sequence is
in conflict with the conceptual translation"
/codon_start=1
/db_xref="PID:e25011"
/db_xref="PID:g1334904"
/db_xref="SWISS-PROT:P30119"
/translation="NERLPFSWPTCAKRQPPSTAVMLKCKQPGARFIHGAVHLPSGQI
VFHTIHSPTLASALGLPGENVPIPALFRASGLNVRESLPMTNMRAPIISLARLILAPN
PYILEGQLTVGMTQDNGIPVLFARPVIEVKSGPESNIKASSQLMIAEDSCLNQIAPFS
ASEHPAFSMVESVKRVRVDEGANTRRTIRDILEIPVTVLSSLQLSPTKSILKKAPEPP
PPEPQATFDATPYARIFYDIGRQVPKLGNAPAAQVSNVLIANRSHNSLRLVPNPDLLP
LQHLYLKHVVLKSLNLENIVQDFEAIFTSPSDTISEAETKAFEKLVEQAKNTVENIVF
CLNSICSTSTLPDVVPDVNNPNISLALEKYFLMFPPSGTIMRNVRFATPIVRLLCQGA
ELGTMAQFLGKYIKVKKETGMYTLVKLYYLLRI"
misc_feature complement(140902)
/note="polyA signal: AATAAA, 3' end of 2.5kb late RNA"
CDS complement(140916..143036)
/note="BXLF2 late reading frame, encodes gp85; homologous
to RF 37 VZV and glycoprotein H of HSV (gpIII of VZV)"
/codon_start=1
/db_xref="PID:g1334905"
/db_xref="SWISS-PROT:P03231"
/translation="MQLLCVFCLVLLWEVGAASLSEVKLHLDIEGHASHYTIPWTELM
AKVPGLSPEALWREANVTEDLASMLNRYKLIYKTSGTLGIALAEPVDIPAVSEGSMQV
DASKVHPGVISGLNSPACMLSAPLEKQLFYYIGTMLPNTRPHSYVFYQLRCHLSYVAL
SINGDKFQYTGAMTSKFLMGTYKRVTEKGDEHVLSLVFGKTKDLPDLRGPFSYPSLTS
AQSGDYSLVIVTTFVHYANFHNYFVPNLKDMFSRAVTMTAASYARYVLQKLVLLEMKG
GCREPELDTETLTTMFEVSVAFFKVGHAVGETGNGCVDLRWLAKSFFELTVLKDIIGI
CYGATVKGMQSYGLERLAAMLMATVKMEELGHLTTEKQEYALRLATVGYPKAGVYSGL
IGGATSVLLSAYNRHPLFQPLHTVMRETLFIGSHVVLRELRLNVTTQGPNLALYQLLS
TALCSALEIGEVLRGLALGTESGLFSPCYLSLRFDLTRDKLLSMAPQEATLDQAAVSN
AVDGFLGRLSLEREDRDAWHLPAYKCVDRLDKVLMIIPLINVTFIISSDREVRGSALY
EASTTYLSSSLFLSPVIMNKCSQGAVAGEPRQIPKIQNFTRTQKSCIFCGFALLSYDE
KEGLETTTYITSQEVQNSILSSNYFDFDNLHVHYLLLTTNGTVMEIAGLYEERAHVVL
AIILYFIAFALGIFLVHKIVMFFL"
misc_feature 140970
/note="polyA signal: AATAAA"
misc_feature complement(141286)
/note="polyA signal: AATAAA"
promoter 142589
/note="TATA: GATAAAA"
misc_feature 142740
/note="BAM: Bam H1 T/X"
CDS complement(143038..144861)
/note="BXLF1 early reading frame, thymidine kinase
(Littler et al, 1986). Weak homology to RF 36 VZV and HSV
thymidine kinase. 4.0kb early RNA presumably encodes the
TK. Also a 2.2kb late RNA here."
/codon_start=1
/db_xref="PID:g1334907"
/db_xref="SWISS-PROT:P03177"
/translation="MAGFPGKEAGPPGGWRKCQEDESPENERHENFYAEIDDFAPSVL
TPTGSDSGAGEEDDDGLYQVPTHWPPLMAPTGLSGERVPCRTQAAVTSNTGNSPGSRH
TSCPFTLPRGAQPPAPAHQKPTAPTPKPRSRECGPSKTPDPFSWFRKTSCTEGGADST
SRSFMYQKGFEEGLAGLGLDDKSDCESEDESNFRRPSSHSALKQKNGGKGKPSGLFEH
LAAHGREFSKLSKHAAQLKRLSGSVMNVLNLDDAQDTRQAKAQRKESMRVPIVTHLTN
HVPVIKPACSLFLEGAPGVGKTTMLNHLKAVFGDLTIVVPEPMRYWTHVYENAIKAMH
KNVTRARHGREDTSAEVLACQMKFTTPFRVLASRKRSLLVTESGARSVAPLDCWILHD
RHLLSASVVFPLMLLRSQLLSYSDFIQVLATFTADPGDTIVWMKLNVEENMRRLKKRG
RKHESGLDAGYLKSVNDAYHAVYCAWLLTQYFAPEDIVKVCAGLTTITTVCHQSHTPI
IRSGVAEKLYKNSIFSVLKEVIQPFRADAVLLEVCLAFTRTLAYLQFVLVDLSEFQDD
LPGCWTEIYMQALKNPAIRSQFFDWAGLSKVISDFERGNRD"
promoter complement(143310)
/note="TATA: TATAAGA ECL2 late promoter before BXLF2,
gives 2.5kb late RNA"
misc_feature 143608
/note="polyA signal: AATAAA"
misc_feature 144791
/note="ACCEPT: TCTTTCGTTTTCAGG poss. acceptor before
BXRF1"
CDS 144860..145606
/note="BXRF1 late reading frame, homologous to RF 35 VZV.
Basic (core?) protein."
/codon_start=1
/db_xref="PID:g1334906"
/db_xref="SWISS-PROT:P03232"
/translation="MDPTRGLCALSTHDLAKFHSLPPARKAAGKRAHLRCYSKLLSLK
SWEQLASFLSLPPGPTFTDFRLFFEVTLGRRIADCVVVALQPYPRCYIVEFKTAMSNT
ANPQSVTRKAQRLEGTAQLCDCANFLRTSCPPVLGSQGLEVLAALVFKNQRSLRTLQV
EFPALGQKTLPTSTTGLLNLLSRWQDGALRARLDRPRPTAQGHRPRTHVGPKPSQLTA
RVPRSARAGRAGGRKGQVGAVGQVCPGAQK"
misc_feature 144862
/note="BAM: Bam H1 X/V"
misc_feature 144945
/note="DONOR: CAGGTAAGC possible donor at 3' BXRF1"
promoter complement(145135)
/note="TATA: TATAACA before BXLF1"
promoter 145302
/note="TATA: TATTTAA before BVRF1, potential promoter for
1.9kb early RNA"
CDS 145416..147128
/note="BVRF1 early reading frame, homologous to RF 34 VZV"
/codon_start=1
/db_xref="PID:g1334908"
/db_xref="SWISS-PROT:P03233"
/translation="MALSGHVLIDPARLPRDTGPELMWAPSLRNSLRVSPEALELAER
EAERARSERWDRCAQVLKNRLLRVELDGIMRDHLARAEEIRQDLDAVVAFSDGLESMQ
VRSPSTGGRSAPAPPSPSPAQPFTRLTGNAQYAVSISPTDPPLMVAGSLAQTLLGNLY
GNINQWVPSFGPWYRTMSANAMQRRVFPKQLRGNLNFTNSVSLKLMTEVVAVLEGTTQ
DFFSDVRHLPDLQAALILSVAYLLLQGGSSHQQRPLPASREELLELGPESLEKIIADL
KAKSPGGNFMILTSGNKEARQSIAPLNRQAAYPPGTFADNKIYNLFVGAGLLPTTAAL
NVPGAAGRDRDLVYRIANQIFGEDVPPFSSHQWNLRVGLAALEALMLVYTLCETANLA
EAATRRLHLSSLLPQAMQRRKPAMASAGMPGAYPVQTLFRHGELFRFIWAHYVRPTVA
ADPQASISSLFPGLVLLALELKLMDGQAPSHYAINLTGQKFDTLFEIINQKLLFHDPA
AMLAARTQLRLAFEDGVGVALGRPSPMLAAREILERQFSASDDYDRLYFLTLGYLASP
VAPS"
misc_feature complement(146926)
/note="polyA signal: AATAAA"
misc_feature 147167
/note="DONOR: AAGGTAAAT possible donor"
misc_feature 147170
/note="polyA signal: AATAAA, 3' end of 2.4kb late and
1.9kb early RNAs"
promoter 147721
/note="TATA: TATTTAT before BVRF2, potential promoter for
2.1kb early RNA"
CDS 147927..149744
/note="BVRF2 early reading frame, N-terminus homologous to
RF 33 VZV"
/codon_start=1
/db_xref="PID:g1334909"
/db_xref="SWISS-PROT:P03234"
/translation="MVQAPSVYVCGFVERPDAPPKDACLHLDPLTVKSQLPLKKPLPL
TVEHLPDAPVGSVFGLYQSRAGLFSAASITSGDFLSLLDSIYHDCDIAQSQRLPLPRE
PKVEALHAWLPSLSLASLHPDIPQTTADGGKLSFFDHVSICALGRRRGTTAVYGTDLA
WVLKHFSDLEPSIAAQIENDANAAKRESGCPEDHPLPLTKLIAKAIDAGFLRNRVETL
RQDRGVANIPAESYLKASDAPDLQKPDKALQSPPPASTDPATMLSGNAGEGATACGGS
AAAGQDLISVPRNTFMTLLQTNLDNKPPRQTPLPYAAPLPPFSHQAIATAPSYGPGAG
AVAPAGGYFTSPGGYYAGPAGGDPGAFLAMDAHTYHPHPHPPPAYFGLPGLFGPPPPV
PPYYGSHLRADYVPAPSRSNKRKRDPEEDEEGGGLFPGEDATLYRKDIAGLSKSVNEL
QHTLQALRRETLSYGHTGVGYCPQQGPCYTHSGPYGFQPHQSYEVPRYVPHPPPPPTS
HQAAQAQPPPPGTQAPEAHCVAESTIPEAGAAGNSGPREDTNPQQPTTEGHHRGKKLV
QASASGVAQSKEPTTPKAKSVSAHLKSIFCEELLNKRVA"
misc_feature 148007
/note="BAM: Bam H1 V/d"
promoter 148620
/note="TATA: TATTTAA ECR1 late promoter before BdRF1,
gives 1.2kb late RNA"
CDS 148707..149744
/note="BdRF1 reading frame; this is the C terminus of
BVRF2"
/codon_start=1
/db_xref="PID:g1334910"
/translation="MLSGNAGEGATACGGSAAAGQDLISVPRNTFMTLLQTNLDNKPP
RQTPLPYAAPLPPFSHQAIATAPSYGPGAGAVAPAGGYFTSPGGYYAGPAGGDPGAFL
AMDAHTYHPHPHPPPAYFGLPGLFGPPPPVPPYYGSHLRADYVPAPSRSNKRKRDPEE
DEEGGGLFPGEDATLYRKDIAGLSKSVNELQHTLQALRRETLSYGHTGVGYCPQQGPC
YTHSGPYGFQPHQSYEVPRYVPHPPPPPTSHQAAQAQPPPPGTQAPEAHCVAESTIPE
AGAAGNSGPREDTNPQQPTTEGHHRGKKLVQASASGVAQSKEPTTPKAKSVSAHLKSI
FCEELLNKRVA"
misc_feature 149115
/note="BAM: Bam H1 d/I"
misc_feature 149727
/note="polyA signal: AATAAA, 3' end of 2.1kb early and
1.2kb late RNAs"
misc_feature complement(149758)
/note="polyA signal: AATAAA, 3' end of 1.0kb late, 1.5kb
late and 1.8kb late RNAs"
CDS complement(149779..150525)
/note="BILF2 late reading frame 11xNXT/S"
/codon_start=1
/db_xref="PID:g1334911"
/db_xref="SWISS-PROT:P03218"
/translation="MTHLVLLLCCCVGSVCAFFSDLVKFENVTAHAGARVNLTCSVPS
NESVSRIELGRGYTPGDGQLPLAVATSNNGTHITNGGYNYSLTLEWVNDSNTSVSLII
PNVTLAHAGYYTCNVTLRNCSVASGVHCNYSAGEEDDQYHANRTLTQRMHLTVIPATT
IAPTTLVSHTTSTSHRPHRRPVSKRPTHKPVTLGPFPIDPWRPKTTWVHWALLLITCA
VVAPVLLIIIISCLGWLAGWGRRRKGWIPL"
promoter complement(150571)
/note="TATA: TATTTAG before BILF2. Potential promoter for
1.0kb late RNA."
repeat_region 151236..151618
/note="repetitive sequence 3X"
misc_feature 151767
/note="polyA signal: AATAAA"
promoter complement(151780)
/note="TATA: CATAAAA"
misc_feature 152012..152013
/note="DEL: B95-8 deletion with respect to Raji"
CDS complement(152161..153099)
/note="BILF1 reading frame, membrane protein, 3xNXS /T"
/codon_start=1
/db_xref="PID:g1334912"
/db_xref="SWISS-PROT:P03208"
/translation="MLSTMAPGSTVGTLVANMTSVNATEDACTKSYSAFLSGMTSLLL
VLLILLTLAGILFIIFVRKLVHRMDVWLIALLIELLLWVLGKMIQEFSSTGLCLLTQN
MMFLGLMCSVWTHLGMALEKTLALFSRTPKRTSHRNVCLYLMGVFCLVLLLIIILLIT
MGPDANLNRGPNMCREGPTKGMHTAVQGLKAGCYLLAAVLIVLLTVIIIWKLLRTKFG
RKPRLICNVTFTGLICAFSWFMLSLPLLFLGEAGSLGFDCTESLVARYYPGPAACLAL
LLIILYAWSFSHFMDSLKNQVTVTARYFRRVPSQST"
promoter 152230
/note="TATA: CATAAAA"
misc_feature 153259
/note="polyA signal: AATAAA"
misc_feature 153637
/note="HPN: 22bp 2-fold symmetric"
misc_feature complement(153690)
/note="DONOR: AAAGTGAGG possible donor"
CDS complement(153699..156746)
/note="BALF5 DNA polymerase (early), homologous to many
DNA polymerases, CMV HFLF2 and RF 28 VZV. 4.5kb early RNA
apparently encodes BALF5, RNA ends unknown."
/codon_start=1
/db_xref="PID:g1334913"
/db_xref="SWISS-PROT:P03198"
/translation="MSGGLFYNPFLRPNKGLLKKPDKEYLRLIPKCFQTPGAAGVVDV
RGPQPPLCFYQDSLTVVGGDEDGKGMWWRQRAQEGTARPEADTHGSPLDFHVYDILET
VYTHEKCAVIPSDKQGYVVPCGIVIKLLGRRKADGASVCVNVFGQQAYFYASAPQGLD
VEFAVLSALKASTFDRRTPCRVSVEKVTRRSIMGYGNHAGDYHKITLSHPNSVCHVAT
WLQDKHGCRIFEANVDATRRFVLDNDFVTFGWYSCRRAIPRLQHRDSYAELEYDCEVG
DLSVRREDSSWPSYQALAFDIECLGEEGFPTATNEADLILQISCVLWSTGEEAGRYRR
ILLTLGTCEDIEGVEVYEFPSELDMLYAFFQLIRDLSVEIVTGYNVANFDWPYILDRA
RHIYSINPASLGKIRAGGVCEVRRPHDAGKGFLRANTKVRITGLIPIDMYAVCRDKLS
LSDYKLDTVARHLLGAKKEDVHYKEIPRLFAAGPEGRRRLGMYCVQDSALVMDLLNHF
VIHVEVAEIAKIAHIPCRRVLDDGQQIRVFSCLLAAAQKENFILPMPSASDRDGYQGA
TVIQPLSGFYNSPVLVVDFASLYPSIIQAHNLCYSTMITPGEEHRLAGLRPGEDYESF
RLTGGVYHFVKKHVHESFLASLLTSWLAKRKAIKKLLAACEDPRQRTILDKQQLAIKC
TCNAVYGFTGVANGLFPCLSIAETVTLQGRTMLERAKAFVEALSPANLQALAPSPDAW
APLNPEGQLRVIYGDTDSLFIECRGFSESETLRFADALAAHTTRSLFVAPISLEAEKT
FSCLMLITKKRYVGVLTDGKTLMKGVELVRKTACKFVQTRCRRVLDLVLADARVKEAA
SLLSHRPFQESFTQGLPVGFLPVIDILNQAYTDLREGRVPMGELCFSTELSRKLSAYK
STQMPHLAVYQKFVERNEELPQIHDRIQYVFVEPKGGVKGARKTEMAEDPAYAERHGV
PVAVDHYFDKLLQGAANILQCLFDNNSGAALSVLQNFTARPPF"
misc_feature 154747
/note="BAM: Bam H1 I/A"
misc_feature complement(156707)
/note="polyA signal: AATAAA; 3' end of 2.5kb late (gB) RNA
and 1.8kb late RNA"
CDS complement(156749..159322)
/note="BALF4 late reading frame 9xNXT/S homologous to HSV1
glycoprotein B (Pellet et al, 1985), CMV HFLF1 and RF 31
VZV (gpII)"
/codon_start=1
/db_xref="PID:g1334914"
/db_xref="SWISS-PROT:P03188"
/translation="MTRRRVLSVVVLLAALACRLGAQTPEQPAPPATTVQPTATRQQT
SFPFRVCELSSHGDLFRFSSDIQCPSFGTRENHTEGLLMVFKDNIIPYSFKVRSYTKI
VTNILIYNGWYADSVTNRHEEKFSVDSYETDQMDTIYQCYNAVKMTKDGLTRVYVDRD
GVNITVNLKPTGGLANGVRRYASQTELYDAPGWLIWTYRTRTTVNCLITDMMAKSNSP
FDFFVTTTGQTVEMSPFYDGKNKETFHERADSFHVRTNYKIVDYDNRGTNPQGERRAF
LDKGTYTLSWKLENRTAYCPLQHWQTFDSTIATETGKSIHFVTDEGTSSFVTNTTVGI
ELPDAFKCIEEQVNKTMHEKYEAVQDRYTKGQEAITYFITSGGLLLAWLPLTPRSLAT
VKNLTELTTPTSSPPSSPSPPAPSAARGSTPAAVLRRRRRDAGNATTPVPPTAPGKSL
GTLNNPATVQIQFAYDSLRRQINRMLGDLARAWCLEQKRQNMVLRELTKINPTTVMSS
IYGKAVAAKRLGDVISVSQCVPVNQATVTLRKSMRVPGSETMCYSRPLVSFSFINDTK
TYEGQLGTDNEIFLTKKMTEVCQATSQYYFQSGNEIHVYNDYHHFKTIELDGIATLQT
FISLNTSLIENIDFASLELYSRDEQRASNVFDLEGIFREYNFQAQNIAGLRKDLDNAV
SNGRNQFVDGLGELMDSLGSVGQSITNLVSTVGGLFSSLVSGFISFFKNPFGGMLILV
LVAGVVILVISLTRRTRQMSQQPVQMLYPGIDELAQQHASGEGPGINPISKTELQAIM
LALHEQNQEQKRAAQRAAGPSVASRALQAARDRFPGLRRRRYHDPETAAALLGEAETE