Division of Tumor Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.
J Virol 64: 4549-52 (1990)
Abstract
The Epstein-Barr virus BZLF1 gene product ZEBRA is a DNA-binding
protein that is partially homologous to c-Fos, binds specifically to
AP-1 sites, and can induce the lytic cycle in latently infected B
lymphocytes. Induction of the viral lytic cycle can also be achieved by
treatment with the phorbol ester 12-O-tetrade-canoylphorbol-13-acetate,
a reagent which activates gene expression in part through AP-1
(Jun/Fos). In this article the interrelationship between ZEBRA and AP-1
is extended by the demonstration that ZEBRA can induce c-Fos expression
through AP-1 and "AP-1-like" sites present in the c-fos promoter.
Induction of c-Fos may be necessary for the expression of other viral
lytic genes and perhaps cellular genes whose products are required for
viral replication.
Mesh Headings
Unique Identifier: 90347854
Chemical Identifiers (Names)