LAB PUBLICATIONS
1990-2001
Jung, EJ, Flemington, EK. Transfection Mediated Cell Synchronization: Acceleration of G1-S Phase Transition by Gamma Irradiation. Biotechniques 2001; 31: 1031-4.
Rodriguez, A, Jung, EJ, Yin, Q, Cayrol, C, Flemington, EK. Role of c-myc regulation in Zta mediated induction of the cyclin dependent kinase inhibitors, p21 and p27, and cell growth arrest. Virology 2001; 284:159-169.
Flemington, EK. Herpesviral lytic replication and the cell cycle: Arresting new developments. J Virol 2001; 75:4475-4481.
Rodriguez A,Jung, EJ, Flemington, EK. Cell cycle analysis of Epstein Barr virus infected cells following treatment with lytic cycle inducing agents. J Virol 2001; 75:4482-4489.
Campanero MR, Armstrong M, and Flemington EK. CpG methylation as a novel mechanism for the regulation of E2F activity. Proc Natl Acad Sci USA 2000; 97:6481-8486.
Campanero MR, Armstrong M, and Flemington EK. Molecular basis for the unique regulation of the c-myb promoter through its E2F element. Mol Cell Biol 1999; 19:8442-8450.
Rodriguez A, Armstrong M, Dwyer, D and Flemington EK. Genetic dissection of cell growth arrest functions mediated by the Epstein-Barr virus lytic gene product, Zta. J Virol 1999; 73:9029-9038.
Rodriguez A, and Flemington EK. Transfection mediated cell cycle signaling. Anal Bio 1999; 272:171-181.
Campanero MR, Flemington EK. Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein. Proc. Natl. Acad. Sci. USA, (1997) 94: 2221-2226.
Cayrol C, Flemington EK. Go/G1 Growth arrest mediated by a region encompassing the bZIP domain of the Epstein-Barr virus transactivator Zta. J. Biol. Chem. (1996) 271: 31799-31802.
Cayrol C, Flemington EK. The Epstein-Barr virus bZIP transcription factor Zta causes Go/G1 cell-cycle arrest through induction of cyclin dependent kinase inhibitors. EMBO J. (1996) 15:2748-2759.
Cayrol C, Flemington EK. Identification of cellular target genes of the Epstein-Barr virus transactivator, Zta. J Virol. (1995) 69:4206-4212.
Goldfeld AE, Liu P, Liu S, Flemington EK, Strominger JL, and Speck SH. Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. Virology. (1995) 209:225-229.
Bodor J, Walker W, Flemington E, Spetz AL, Habener JF. Modulation of tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM. FEBS (1995) 377:413-418.
Flemington EK, Lytle JP, Cayrol C, Borras AM, Speck SH. DNA binding defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivates with altered specificities. Mol Cell Biol. (1994) 14:3041-3052.
Neuman E, Flemington EK, Sellers WR, Kaelin WG Jr. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol Cell Biol. (1994) 14:6607-6615.
Flemington EK, speck SH, Kaelin WG Jr. E2F-1 mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc Natl Acad Sci USA. (1993) 90:6914-6918.
Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum R, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA, Livingston D, Flemington EK. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 70:351-364.
Goldfeld AE, Flemington E, Boissiotis VA, Theodos CM, Titus RG, Strominger JL, Speck SH. Transcription of the tumor necrosis factor-alpha gene is rapidly induced by anti-immunoglobulin and blocked by Cyclosporin A and FK506 in human B-cells. Proc Natl Acad Sci USA. (1992) 89:12198-12201.
Flemington E, Borras A, Lytle J, Speck SH. Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain. J Virol. (1992) 66:922-929.
Flemington E, Goldfeld AE, Speck SH. Efficient transcription of the Epstein-Barr virus immediate early BZLF1 and BRLF1 genes requires protein synthesis. J Virol. (1991) 65:7073-7077.
Taylor N, Flemington E, Kolman J, Baumann R, Speck S, Miller G. Zebra and Fos/Jun proteins differ in their DNA-binding specificities. J Virol. (1991) 65:4033-4041.
Flemington E, Speck SH. Evidence for coiled coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues. Proc. Natl. Sci USA. (1990) 87:9459-9463.
Flemington E, Speck SH. Epstein-Barr virus BZLF1 trans-activator induces the promoter of a cellular cognate gene, c-fos. J Virol. (1990) 64:4549-4552.
Flemington E, Speck SH. Autoregulation of the Epstein-Barr virus putative lytic switch gene BZLF1. J Virol. (1990) 64:1227-1232.
Flemington E, Speck SH. Identification of phorbol ester response elements in the promoter of the Epstein-Barr virus putative lytic switch gene, BZLF1. J Virol. (1990); 64:1217-1226.